Depression Prevention Program for Adolescents

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00183417
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : April 25, 2012
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
University of Texas at Austin

Brief Summary:
This study will compare the effectiveness of two programs designed to prevent depression in adolescents.

Condition or disease Intervention/treatment Phase
Depression Behavioral: Cognitive behavior therapy (CBT) Behavioral: Supportive/expressive (S/E) therapy Behavioral: Bibliotherapy Not Applicable

Detailed Description:

Major depression is one of the most common psychiatric disorders in adolescents. In many cases, the condition is recurrent and can result in serious psychological impairment. A high number of depressed adolescents never receive treatment; therefore, it is crucial to develop prevention programs for this disorder that are effective and can be easily disseminated. This study will evaluate and compare the effectiveness of cognitive behavior therapy (CBT) and supportive/expressive (S/E) therapy in preventing depressive symptoms in adolescents.

This study will last 2 years. Participants will be randomly assigned to receive six sessions of CBT, S/E therapy, or standard depression education over 2 years. The CBT intervention will focus on reducing negative thoughts and increasing engagement in pleasant activities. S/E therapy is designed to allow adolescents to express their negative emotions and talk about recent stressful events in a supportive environment of their peers. Surveys and psychiatric interviews will be completed by all participants and their parents at the beginning and the end of the study. The surveys and interviews will assess depressive symptoms.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 350 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Depression Prevention Program for High-Risk Adolescents
Study Start Date : September 2004
Actual Primary Completion Date : May 2009
Actual Study Completion Date : May 2009

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: 1
Participants will receive cognitive behavioral therapy
Behavioral: Cognitive behavior therapy (CBT)
Participants will complete worksheets and group discussion on how to increase positive mood and activity.

Active Comparator: 2
Participants will receive supportive/expressive therapy
Behavioral: Supportive/expressive (S/E) therapy
Participants will be encouraged to express feelings and emotions without advice giving.

Active Comparator: 3
Participants will receive bibliotherapy
Behavioral: Bibliotherapy
Participants will be given a book on how to increase their mood.

No Intervention: 4
Participants in the control condition will receive no treatment

Primary Outcome Measures :
  1. Depressive symptoms [ Time Frame: Measured at Year 1 ]

Information from the National Library of Medicine

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Ages Eligible for Study:   14 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Beck Depression Inventory score higher than 10
  • Parent or guardian willing to provide informed consent

Exclusion Criteria:

  • Diagnosis of depression

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00183417

United States, Texas
University of Texas at Austin
Austin, Texas, United States, 78712
Sponsors and Collaborators
University of Texas at Austin
National Institute of Mental Health (NIMH)
Principal Investigator: Eric M. Stice, PhD University of Texas at Austin

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: University of Texas at Austin Identifier: NCT00183417     History of Changes
Other Study ID Numbers: R01MH067183 ( U.S. NIH Grant/Contract )
R01MH067183 ( U.S. NIH Grant/Contract )
First Posted: September 16, 2005    Key Record Dates
Last Update Posted: April 25, 2012
Last Verified: April 2012

Keywords provided by University of Texas at Austin:

Additional relevant MeSH terms:
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders