This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Canadian Pulmonary Embolism Diagnosis Study (CANPEDS)

This study has been terminated.
Canadian Institutes of Health Research (CIHR)
Information provided by:
McMaster University Identifier:
First received: September 13, 2005
Last updated: April 27, 2006
Last verified: August 2005

The main objective of the trial is to determine whether D-dimer testing combined with assessment of Pre-Test-Probability (using a standardized clinical model) can be used to markedly simplify the diagnostic process for PE.

It may be safe to omit additional diagnostic testing in selected patients with suspected pulmonary embolism who have a negative D-dimer test

Condition Intervention Phase
Suspected Pulmonary Embolism Deep Venous Thrombosis Procedure: Two diagnostic management strategies Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Canadian Pulmonary Embolism Diagnosis Study

Resource links provided by NLM:

Further study details as provided by McMaster University:

Primary Outcome Measures:
  • DVT or PE during 6 months follow-up

Secondary Outcome Measures:
  • bleeding

Estimated Enrollment: 1126
Study Start Date: August 1998
Estimated Study Completion Date: January 2001
Detailed Description:
To assess the value of the D-dimer in the diagnosis of PE, we had two sub-groups of patients with suspected PE, low and high pre-test probability. Patients could be randomized either to further or no further testing.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with clinically suspected PE

Exclusion Criteria:

  • Treatment with anticoagulants for greater than 24 hours of performance of D-d
  • Comorbid condition limiting survival to less than 3 months
  • Absence of acute symptoms within 7 days prior to presentation
  • Current pregnancy
  • Contraindication to contrast (e.g., allergy, renal failure)
  • Geographic inaccessibility which precludes follow-up
  • Physician believes patient is inappropriate for study
  • failure or inability to provide informed consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00182546

Canada, Nova Scotia
Queen Elizabeth II Health Sciences Ctr.
Halifax, Nova Scotia, Canada, B3H 1V7
Canada, Ontario
Alexander G. Turpie
Hamilton, Ontario, Canada, L8L 2X2
McMaster University Medical Centre
Hamilton, Ontario, Canada, L8N 3Z5
James Douketis
Hamilton, Ontario, Canada, L8N 4A6
HHSC Henderson Campus
Hamilton, Ontario, Canada, L8V 1C3
London Health Sciences Centre
London, Ontario, Canada, N6A 4G5
Ottawa Civic Hospitals
Ottawa, Ontario, Canada, K1Y 1J8
Sponsors and Collaborators
Hamilton Health Sciences Corporation
Canadian Institutes of Health Research (CIHR)
Study Chair: Clive Kearon, MD, PhD McMaster University
Principal Investigator: Jeffrey S Ginsberg, MD McMaster University
Principal Investigator: James Douketis, MD McMaster University
Principal Investigator: Alexander G Turpie, MB McMaster University
Principal Investigator: Shannon M Bates, MDCM McMaster University
Principal Investigator: Mark A Crowther, MD McMaster University
Principal Investigator: Jeffrey I Weitz, MD McMaster University
Principal Investigator: Michael Gent, DSc McMaster University
Principal Investigator: Agnes Y Lee, MD McMaster University
  More Information Identifier: NCT00182546     History of Changes
Other Study ID Numbers: CTMG-1999-CANPEDS
Study First Received: September 13, 2005
Last Updated: April 27, 2006

Keywords provided by McMaster University:
Pulmonary Embolism
Venous Thrombosis
D dimer

Additional relevant MeSH terms:
Pulmonary Embolism
Venous Thrombosis
Embolism and Thrombosis
Vascular Diseases
Cardiovascular Diseases
Lung Diseases
Respiratory Tract Diseases processed this record on September 21, 2017