Evaluation of Volume Status in Peritoneal Dialysis Patients
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|ClinicalTrials.gov Identifier: NCT00182338|
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : July 20, 2011
|Condition or disease|
|Cardiovascular Diseases Inflammation Peritoneal Dialysis|
Patients with end-stage renal disease (ESRD) have a higher risk than the general population of developing premature cardiovascular disease; the reasons for this are complex. Two recent randomized controlled trials in peritoneal dialysis patients have demonstrated that targeting patients to higher dialysis clearance values is not associated with a reduction in mortality. It is known that patients on peritoneal dialysis are more likely to be volume expanded, develop left ventricular hypertrophy, and have inadequate blood pressure relative to patients on hemodialysis. As a result there has been increased attention on the role of fluid management in reducing the risk of developing congestive heart failure and other adverse cardiovascular events in peritoneal dialysis patients.
Extracellular fluid volume and total body water can be accurately assessed with multi-frequency bioimpedance analysis (BIA). Estimation of volume expansion by measuring the natriuretic peptide N-BNP produced by cardiac tissue in response to ventricular wall stretch can also be used.
The purpose of this study is to determine whether volume status, as measured by BIA and N-BNP levels, correlates with clinical volume assessment, cardiovascular outcomes, peritoneal membrane transport properties and markers of inflammation such as serum albumin and C-reactive protein.
|Study Type :||Observational|
|Actual Enrollment :||22 participants|
|Official Title:||Evaluation of Volume Status in Peritoneal Dialysis Patients|
|Study Start Date :||January 2005|
|Actual Primary Completion Date :||January 2009|
|Actual Study Completion Date :||January 2009|
|Peritoneal Dialysis Patients|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00182338
|St. Joseph's Healthcare|
|Hamilton, Ontario, Canada, L8N 4A6|
|Principal Investigator:||Scott K Brimble, MD||McMaster University|
|Study Director:||Peter Margetts, MD, PhD||McMaster University|
|Study Director:||David N Churchill, MD, MSc||McMaster University|
|Study Director:||Azim S Gangji, MD||McMaster University|