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Concerta Treatment in Adults With ADHD NOS

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00181740
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : July 23, 2010
McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.
Information provided by:
Massachusetts General Hospital

Brief Summary:
This will be an open label pilot study of Concerta in the treatment of adults with the diagnosis of Attention Deficit Hyperactivity Disorder Not Otherwise Specified (ADHD NOS). We hypothesize ADHD symptomatology in adults with ADHD NOS will be responsive to Concerta treatment in the short term and Concerta-associated response of ADHD symptomatology in adults with ADHD NOS will be sustained over the medium term.

Condition or disease Intervention/treatment Phase
ADHD NOS Drug: atomoxetine (Strattera) Phase 4

Detailed Description:

Concerta is a stimulant medication approved for the treatment of ADHD in children. We propose to study the safety and efficacy of Concerta therapy in adults with ADHD NOS. Adult ADHD NOS is operationalized by either

  • An adult satisfying current diagnostic criteria for ADHD but with insufficient number of childhood symptoms to fulfill the required diagnostic threshold for this disorder set forth in DSM-IV
  • An adult who has five current symptoms of inattention and/or five current symptoms of impulsivity/hyperactivity, but does not meet the full diagnosis criteria of six current symptoms within one of these categories.

Our hypotheses will be examined in two phases of an open label, pilot study. Phase I of the study consists of a six-week acute effectiveness trial. Phase II consists of continuation for responders in which subjects who respond in Phase I will be re-assessed every four weeks for six months. Effectiveness will be measured by improvements in clinician-rated scales, including: ADHD Symptom Checklist, Clinical Global Impression: ADHD, and Global Assessment of Functioning.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 30 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Pilot Study of Concerta Treatment in Adults With Attention Deficit Hyperactivity Disorder Not Otherwise Specified
Study Start Date : December 2003
Actual Study Completion Date : July 2005

Primary Outcome Measures :
  1. improvement of ADHD symptoms as related by scores on the
  2. ADHD Symptom Checklist
  3. Clinical Global Impression: ADHD
  4. Global Assessment of Functioning

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Male and female outpatients older than 18 and younger than 55 years of age.
  2. Subjects with the diagnosis of Attention Deficit Hyperactivity Disorder Not Otherwise Specified (ADHD NOS), by DSM-IV, as manifested in clinical evaluation and confirmed by structured interview. This is operationalized by either

    • Having at least 5 out of 9 current DSM-IV items of either inattention or hyperactivity/impulsivity but < 5 items from either list in childhood
    • Having 5 out of 9 current DSM-IV items of either inattention or hyperactivity/impulsivity, but not having the 6 current symptoms in either category. This second category will be included independent of the presence or absence of ADHD symptoms in childhood.
  3. Subjects will have a current Clinical Global Impression: ADHD score of 4 (moderately ill) or higher illness severity.
  4. Patients with past history of depression, bipolar disorder, anxiety disorder (including OCD) without current disorder for > 3 months as ascertained through structured diagnostic interview and clinical exam.
  5. Subjects treated for anxiety disorders and depression who are on a stable medication regimen for at least three months, and who have a disorder specific CGI-severity score ≤ 3 (mildly ill) and who have a score on the Hamilton-Depression and Hamilton-anxiety rating scale below 15 (mild range) will be included in the study.
  6. Subjects with a past history of tics but tic free for > 1 year.
  7. Subjects with past history of substance use disorders, but substance free for > 6 months.
  8. Subjects receiving non-MAOI antidepressants (e.g., SSRI's, bupropion, venlafaxine), or benzodiazepines who have been on a stable regimen for > 3 months for any of the conditions listed above. Subjects taking SSRIs will be allowed into the study for the following reasons:

    • SSRIs are not known to interact with methylphenidate
    • Methylphenidate metabolism does not involve the hepatic P450 enzymatic system
    • SSRIs have extremely wide margins of safety
    • SSRIs and methylphenidate are combined routinely in clinical practice.
  9. Subjects with mild cases of asthma and allergy will not be excluded.
  10. Subjects with acid reflux syndrome will not be excluded.
  11. Subjects with hypercholesterolemia will not be excluded.

Exclusion Criteria:

  1. Any clinically unstable psychiatric conditions including the following: acute psychosis, acute panic, acute OCD, acute mania, acute suicidality, bipolar disorder, acute substance use disorders (alcohol or drugs), acute OCD, sociopathy, criminality.
  2. Any metabolic, neurological, hepatic, renal, cardiovascular, hematological, opthalmic, or endocrine disease.
  3. Clinically significant abnormal baseline laboratory values which include the following:

    • Values larger than 20% above the upper range of the laboratory standard of a basic metabolic screen.
    • Exclusionary blood pressure parameters will include any values above 140 (systolic) and 90 (diastolic).
    • Exclusionary ECG parameters will include a QTC> 460msec, QRS>120 msec, and PR>200 msec. Subjects having ECG evidence of ischemia or arrhythmia as reviewed by an independent cardiologist.
  4. Mental retardation (I.Q. <75).
  5. Organic brain disorders.
  6. Seizures or tics in the last year.
  7. Subjects with a family history or diagnosis of Tourette's syndrome.
  8. Subjects who are being treated with monoamine oxidase inhibitors, or have stopped treatment of monoamine oxidase inhibitors for less than 14 days prior to baseline visit.
  9. Subjects taking coumadin anticoagulants, anticonvulsants, or tricyclic antidepressants.
  10. Pregnant or nursing females.
  11. Subjects with current adequate treatment for ADHD or a history of a previous adequate trial of Concerta.
  12. Non English speaking subjects will not be allowed into the study for the following reasons:

    • The assessment instruments are not available and have not been adequately standardized in other languages
    • Our clinical trials facility is located in Cambridge and not in the MGH main campus without the availability of translators
    • Psychiatric questionnaires and evaluations are taxing and adding the complexity of a translator has the potential to make the patient experience even more exhausting.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00181740

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United States, Massachusetts
Massachusetts General Hospital
Cambridge, Massachusetts, United States, 02138
Sponsors and Collaborators
Massachusetts General Hospital
McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.
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Principal Investigator: Joseph Biederman, MD Massachusetts General Hospital

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Responsible Party: Joseph Biederman, MD, Massachusetts General Hospital Identifier: NCT00181740     History of Changes
Other Study ID Numbers: 2003-P-001355
First Posted: September 16, 2005    Key Record Dates
Last Update Posted: July 23, 2010
Last Verified: July 2010
Keywords provided by Massachusetts General Hospital:
Additional relevant MeSH terms:
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Atomoxetine Hydrochloride
Adrenergic Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Adrenergic Agents
Neurotransmitter Agents
Physiological Effects of Drugs
Central Nervous System Stimulants
Dopamine Uptake Inhibitors
Dopamine Agents