Serial CT Scans in Fractionated Stereotactic Radiotherapy
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|ClinicalTrials.gov Identifier: NCT00181350|
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : June 30, 2009
|Condition or disease||Intervention/treatment||Phase|
|Brain Tumor||Device: Relocatable fixation system||Phase 3|
Stereotactic conformal radiotherapy (SCRT) combines the precision of the stereotactically guided tumor localisation and the radiobiological advantages of the fractionation. This implies an highly accurate repositioning of the isocenter of the cerebral target at the isocenter of the linac gantry and couch + 30 times. In the use of stereotactic conformal radiotherapy (SCRT) accuracy is the mainstay for the treatment of brain tumours. The reason are reduced safety margins around the tumour (or no margins) in order to reduce normal tissue dose.
This study aims at providing a quantitative evaluation of the accuracy of two different fixation systems, where one system is also evaluated with two different set-ups. The first approach will be based on the BrainLAB thermoplastic masque (the masque with (= standard fixation) and without a custom made bite-block), the second will use the BrianLAB relocatable frame with the bite- block and a home made fixation system.
Repositioning accuracy will be evaluated in a randomized manner patient-dependent and independent with the two fixation systems mentioned above.
The rationale is to determine the margins to define the planning target volume (PTV), it is necessary to know the set-up accuracy of the immobilization system. An overestimation of the PTV would lead to possible toxicity and an underestimation could lead to a geographical miss.
The main endpoint of this trial will be the accurate reproducibility of the fixation system evaluated by repeated CT scan.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||20 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Serial CT Scans for the Evaluation of Two Different Relocatable Fixation Systems in Fractionated Stereotactic Radiotherapy|
|Study Start Date :||November 2003|
|Actual Study Completion Date :||July 2007|
- CT scanning with a stereotactic lokalizer will take place once a week with a double scan (for 2 fixations) without contrast.
- No secondary measures.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00181350
|Maastricht Radiation Oncology|
|Heerlen, Limburg, Netherlands, 6419 PC|
|Principal Investigator:||Brigitta Baumert, PHD||Maastricht Radiation Oncology|