Efficacy of Transdermal Fentanyl for Chronic Neuropathic Pain
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The efficacy of fentanyl TTS for the treatment of neuropathic pain remains to be established, although opioids in general are clearly effective for neuropathic pain and fentanyl TTS has been shown to be effective for treating other types of pain. We propose to measure functional outcomes, pain relief and side effects of fentanyl TTS for the treatment of neuropathic pain. Measures will be made at baseline and after titrating the drug to an effective level.
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Ages Eligible for Study:
18 Years to 75 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Age >18 years
Neuropathic pain persisting for > 3 months
Pain over the immediate previous three months
The average of the least and usual pain intensity rating of 3 or greater (0-10 numerical rating scale) during the last week prior to enrollment
A history of substance abuse
Allergic reaction to an opioid
Significant pain of alternate etiology other than the neuropathic pain state
Severe pulmonary disease
Recent myocardial infarction (within the preceding three months)
Those with life expectancy of less than six months and HIV seropositivity.
Peripheral Nervous System Diseases
Complex Regional Pain Syndromes
Reflex Sympathetic Dystrophy
Nervous System Diseases
Autonomic Nervous System Diseases
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents