Intravenous Allopurinol in Heart Failure
|ClinicalTrials.gov Identifier: NCT00181155|
Recruitment Status : Completed
First Posted : September 16, 2005
Results First Posted : February 9, 2016
Last Update Posted : May 30, 2017
|Condition or disease||Intervention/treatment||Phase|
|Congestive Heart Failure||Drug: Allopurinol Drug: Placebo||Phase 2|
Xanthine oxidase have been reported to improve mechano-energetic coupling in failing hearts. The investigators developed a means to directly measure creatine kinase flux, the major energy reserve of the heart, in the human heart exploiting new magnetic resonance technologies.
The investigators propose to study 10 healthy subjects and up to 25 with heart failure (dilated cardiomyopathy) before and after a single 300mg IV infusion of allopurinol.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||18 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Effects of Xanthine Oxidase Inhibition on Mechano-Energetic Coupling in Heart Failure|
|Study Start Date :||November 2004|
|Actual Primary Completion Date :||December 2010|
|Actual Study Completion Date :||December 2010|
One time intravenous administration of Allopurinol 300 mg infused over approximately 20 minutes.
intravenous infusion of allopurinol (300mg)
Other Name: Aloprim
Placebo Comparator: Placebo
One time intravenous administration of 50 ml dose of 5% dextrose infused over approximately 20 minutes.
intravenous infusion of 50 ml dose of 5% dextrose
Other Name: 5% Dextrose
- Myocardial Creatine Kinase (CK) Flux Pre Intravenous Allopurinol Infusion [ Time Frame: Onset of imaging acquisition. ]Magnetic resonance spectroscopy (MRS) Measurement of Myocardial CK Flux Pre Intravenous Allopurinol Infusion
- Myocardial CK Flux Post Intravenous Allopurinol Infusion. [ Time Frame: acute (within 15 minutes of single infusion) ]The mean rate of adenosine triphosphate (ATP) flux through the creatine kinase reaction in the heart.
- Cardiac PCr/ATP Pre Intravenous Infusion [ Time Frame: Onset of image acquisition. ]The mean ratio of creatine phosphate (PCr) to ATP in the heart. This measure, as a ratio, is unitless.
- Cardiac PCr/ATP Post Intravenous Infusion [ Time Frame: acute (within 15 minutes of single infusion) ]The mean ratio of creatine phosphate (PCr) to ATP in the heart. This measure, as a ratio, is unitless.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00181155
|United States, Maryland|
|Johns Hopkins Hospital|
|Baltimore, Maryland, United States, 21287|
|Principal Investigator:||Robert G Weiss, MD||Johns Hopkins University|