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Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages

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ClinicalTrials.gov Identifier: NCT00180804
Recruitment Status : Unknown
Verified September 2005 by Imperial College London.
Recruitment status was:  Recruiting
First Posted : September 16, 2005
Last Update Posted : December 14, 2005
Sponsor:
Information provided by:

Study Description
Brief Summary:
For implantation of developing conceptus, placental cells need to invade mother's uterus to access maternal blood supply in a control manner. We have found a combination of maternal immune genes (the KIR family) and fetal genes (HLA-C) strongly associated with pre-eclampsia where placenta does not implant adequately. The aim of this research is to investigate these two genes family in women suffering with recurrent miscarriages and find a possible link between them.

Condition or disease
Recurrent Miscarriages

Detailed Description:
Little is known about reasons for early pregnancy failures. It is believed that some pathology leading to defective implantation of fetus in maternal uterus may lead to recurrent early miscarriages. This project arises from previous work on pre-eclampsia where we found combination of maternal immune genes (KIR) with their ligand (HLA-C) in the fetus was strongly associated with the disease. We will tissue type the fetus, mother and father in cases of unexplained miscarriages. We hope that genetic findings in recurrent miscarriage will lead to new insights, prevention and treatment.

Study Design

Study Type : Observational
Estimated Enrollment : 400 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Retrospective/Prospective
Official Title: Combination of Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages
Study Start Date : April 2005
Estimated Study Completion Date : August 2005

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U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

Couples with 3 or more unexplained miscarriages

Exclusion Criteria:

Previous livebirths, parental karyotypic abnormalities, thrombophilic defects, uterine structural abnormalities

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00180804


Contacts
Contact: Lesley Regan, FRCOG 02078861050 l.regan@imperial.ac.uk

Locations
United Kingdom
St. Mary's Hospital Recruiting
London, United Kingdom, W2 1NY
Contact: Lesley Regan, FRCOG    02078861050    l.regan@imperial.ac.uk   
Sponsors and Collaborators
Imperial College London
Investigators
Principal Investigator: Ashley Moffett, MRCP University of Cambridge, UK
Principal Investigator: Raj Rai, MRCOG Imperial College London
Principal Investigator: Preeti Jindal, MRCOG St. Mary's NHS Trust, London
Principal Investigator: Winnie Lo St. Mary's NHS Trust, London
More Information

ClinicalTrials.gov Identifier: NCT00180804     History of Changes
Other Study ID Numbers: 05/MRE02/20
First Posted: September 16, 2005    Key Record Dates
Last Update Posted: December 14, 2005
Last Verified: September 2005

Additional relevant MeSH terms:
Abortion, Spontaneous
Abortion, Habitual
Pregnancy Complications