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Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2005 by Imperial College London.
Recruitment status was:  Recruiting
Information provided by:
Imperial College London Identifier:
First received: September 13, 2005
Last updated: December 13, 2005
Last verified: September 2005
For implantation of developing conceptus, placental cells need to invade mother's uterus to access maternal blood supply in a control manner. We have found a combination of maternal immune genes (the KIR family) and fetal genes (HLA-C) strongly associated with pre-eclampsia where placenta does not implant adequately. The aim of this research is to investigate these two genes family in women suffering with recurrent miscarriages and find a possible link between them.

Recurrent Miscarriages

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Retrospective/Prospective
Official Title: Combination of Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages

Resource links provided by NLM:

Further study details as provided by Imperial College London:

Estimated Enrollment: 400
Study Start Date: April 2005
Estimated Study Completion Date: August 2005
Detailed Description:
Little is known about reasons for early pregnancy failures. It is believed that some pathology leading to defective implantation of fetus in maternal uterus may lead to recurrent early miscarriages. This project arises from previous work on pre-eclampsia where we found combination of maternal immune genes (KIR) with their ligand (HLA-C) in the fetus was strongly associated with the disease. We will tissue type the fetus, mother and father in cases of unexplained miscarriages. We hope that genetic findings in recurrent miscarriage will lead to new insights, prevention and treatment.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

Couples with 3 or more unexplained miscarriages

Exclusion Criteria:

Previous livebirths, parental karyotypic abnormalities, thrombophilic defects, uterine structural abnormalities

  Contacts and Locations
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Please refer to this study by its identifier: NCT00180804

Contact: Lesley Regan, FRCOG 02078861050

United Kingdom
St. Mary's Hospital Recruiting
London, United Kingdom, W2 1NY
Contact: Lesley Regan, FRCOG    02078861050   
Sponsors and Collaborators
Imperial College London
Principal Investigator: Ashley Moffett, MRCP University of Cambridge, UK
Principal Investigator: Raj Rai, MRCOG Imperial College London
Principal Investigator: Preeti Jindal, MRCOG St. Mary's NHS Trust, London
Principal Investigator: Winnie Lo St. Mary's NHS Trust, London
  More Information Identifier: NCT00180804     History of Changes
Other Study ID Numbers: 05/MRE02/20
Study First Received: September 13, 2005
Last Updated: December 13, 2005

Additional relevant MeSH terms:
Abortion, Spontaneous
Abortion, Habitual
Pregnancy Complications processed this record on September 20, 2017