HDAC Activity in Peripheral Skeletal Muscle in COPD

This study has been completed.
Information provided by:
Imperial College London
ClinicalTrials.gov Identifier:
First received: September 13, 2005
Last updated: August 18, 2008
Last verified: August 2008
We wish to study the effect of Chronic Obstructive Pulmonary Disease on the activity of the nuclear transcription pathway in peripheral skeletal muscle to determine whether altered activity of this pathway may be responsible for the muscle dysfunction observed in these patients.


Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: The Investigation of HDAC and NF Kappa B Activity in Peripheral Skeletal Muscle in COPD

Further study details as provided by Imperial College London:

Estimated Enrollment: 50
Study Start Date: September 2005
Study Completion Date: August 2008
Primary Completion Date: August 2008 (Final data collection date for primary outcome measure)
Detailed Description:
Peripheral muscle dysfunction is well recognised in COPD. We wish to study patients who we have found to have weak quadriceps muscles and study the molecular mechanisms underlying this problem. Patients will be well characterised with regard to their physiologic parameters and quadriceps muscle biopsies will be taken. These biopsy samples will be analysed with respect to NFkappaB activity and HDAC activity by nuclear extraction and for muscle inflammatory cytokines. We know that in the lung tissue of COPD patients there is evidence of a reduction in HDAC activity which might be responsible for the higher levels of pronflammatory cytokines in the lung. We will also study a healthy control group and a small selection of patients who are in respiratory failure due to idiopathic scoliosis in the same way.

Ages Eligible for Study:   40 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

COPD Scoliosis

Exclusion Criteria:

Aspirin therapy Bleeding diasthesis Neuromuscular disease

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00180752

United Kingdom
Royal Brompton Hospital
London, United Kingdom, SW3 6NP
Sponsors and Collaborators
Imperial College London
Principal Investigator: Michael I Polkey, PhD Royal Brompton & Harefield NHS Foundation Trust
  More Information