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Markers for COPD

This study has been completed.
Sponsor:
Collaborator:
AstraZeneca
Information provided by:
Imperial College London
ClinicalTrials.gov Identifier:
NCT00180622
First received: September 9, 2005
Last updated: NA
Last verified: September 2005
History: No changes posted
  Purpose
The primary aim of this study is to exploit a difference between COPD patients, chronic smokers without COPD and healthy non-smoking subjects. This will help to assess the utility of inflammatory and oxidative markers in exhaled air and sputum and to compare them with the lung function, clinical parameters and computerised tomography (CT).

Condition Intervention
Healthy Non-Smokers Current Smokers COPD Patients Procedure: Spirometry Procedure: Exhaled Nitric Oxide and Carbon Monoxide Procedure: Exhaled Breath Condensate Procedure: Induced Sputum Procedure: CT Scan Procedure: Blood test Procedure: St Georges Questionnaire Procedure: Bodypletysmography

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Non-Invasive Markers for COPD

Further study details as provided by Imperial College London:

Estimated Enrollment: 52
Study Start Date: July 2001
  Eligibility

Ages Eligible for Study:   30 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

Healthy non-smokers

  • FEV1 >80% predicted
  • FEV1 reversibility of <10% after inhaled (beta2-agonists

Current smokers

  • FEV1 no less than 80% predicted
  • FEV1 reversibility of <10% after inhaled (beta2-agonists
  • Smoking history of > 10 pack-years

Moderate COPD

  • FEV1 40-59% predicted
  • FEV1 reversibility of <10% after inhaled (beta2-agonists
  • Smoking history of > 10 pack-years**

Severe COPD

  • FEV1 <40% predicted
  • FEV1 reversibility of <10% after inhaled (beta2-agonists
  • Smoking history of > 10 pack-years

Exclusion Criteria:

  • FEV1 increases by 200 ml and 15% of the baseline value after inhaled (beta2-agonists
  • Asthma
  • unstable disease (FEV1 <35% predicted) and/or current, or within the last 4 weeks, respiratory tract infection.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00180622

Locations
United Kingdom
Section of Airway Disease, Asthma Lab, Imperial College London, Royal Brompton Hospital
London, United Kingdom, SW3 6LY
Sponsors and Collaborators
Imperial College London
AstraZeneca
Investigators
Principal Investigator: Sergei A Kharitonov, MD PhD Imperial College London
Principal Investigator: Peter J Barnes, MA DM DSc FRCP Imperial College London
  More Information

ClinicalTrials.gov Identifier: NCT00180622     History of Changes
Other Study ID Numbers: SD-000-068
Study First Received: September 9, 2005
Last Updated: September 9, 2005

Additional relevant MeSH terms:
Nitric Oxide
Carbon Monoxide
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Asthmatic Agents
Respiratory System Agents
Free Radical Scavengers
Antioxidants
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Endothelium-Dependent Relaxing Factors
Vasodilator Agents
Gasotransmitters
Protective Agents
Antimetabolites

ClinicalTrials.gov processed this record on June 23, 2017