VERRARI - "Are Ventricular Arrhythmic Episodes Reduced by Rate Response in ICDs?"
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|ClinicalTrials.gov Identifier: NCT00180427|
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : April 24, 2008
|Condition or disease||Intervention/treatment||Phase|
|Ventricular Fibrillation||Device: ICD||Phase 4|
"Background: Studies have shown that bradycardia and irregular heart rates may increase the incidence of ventricular arrhythmias. Regularizing the heart rate and avoiding bradycardias by rate responsive pacing may be a way to reduce these arrhythmias.
This is a prospective, open-label, randomized multicenter study. Inclusion criteria: Patients with an indication for an ICD according to the AHA/ACC-guidelines who get a rate response system and have more than 5 % rate adaptive pacing during a one month screening phase may be included if they have given written informed consent. Rate adaptive pacing must not be contraindicated, patients must be able to perform a 6 min walk test, must not be NYHA IV and should have a life expectancy of more than 18 months.
Patients will be randomly assigned to 6 months of rate responsive pacing followed by 6 months of no rate responsive pacing, vice versa respectively. At 6 and 12 months follow ups, ICD stored data, arrhythmic episodes, medication, anamnesis, quality of life, 6 min walktest, echocardiographic parameters and optionally spiroergomatry will be evaluated and compared."
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||75 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||VERRARI - "Are Ventricular Arrhythmic Episodes Reduced by Rate Response in ICDs?"|
|Study Start Date :||June 2001|
|Actual Study Completion Date :||November 2004|
- frequency of ventricular arrhythmias at 6 and 12 months follow ups
- medication, anamnesis, quality of life, 6 min walktest, echocardiographic parameters and optionally spiroergomatry at 6 and 12 months follow ups,
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00180427
|Medizinische Klinik der Medizinischen Hochschule|
|Principal Investigator:||Michael Niehaus, MD||Hannover Medical School|