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HLA Matching - Unrelated Umbilical Cord Blood Transplantation

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00179946
First Posted: September 16, 2005
Last Update Posted: January 15, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Ann & Robert H Lurie Children's Hospital of Chicago
  Purpose
The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.

Condition Intervention
Hematologic Diseases Procedure: HLA typing

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Impact of HLA Matching on Outcome in Pediatric Patients Undergoing Unrelated Umbilical Cord Blood Transplantation.

Resource links provided by NLM:


Further study details as provided by Ann & Robert H Lurie Children's Hospital of Chicago:

Estimated Enrollment: 30
Study Start Date: June 2003
Study Completion Date: April 2006
Primary Completion Date: April 2006 (Final data collection date for primary outcome measure)
Detailed Description:

The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.

The study will answer the following questions:

  1. Is HLA matching beneficial to unrelated UCB transplantation?
  2. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 is/are important to math, or alternatively to mismatch, to improve graft survival?
  3. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 mismatches is/are "permissive mismatches" or well tolerated mismatches?
  4. What level of typing resolution (low, intermediate, or hgh) is required to perform patient/donor H:A matching?

By studying the cells and blood of donors and recipients, we may learn more about improving the tissue matching between unrelated donors and their recipients. Also, we hope to learn if an additional level of matching testing improves the results of the transplant treatment. Increasing knowledge about tissue matching could result in the improved long-term survival of cord blood transplant recipients.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Pediatric Patients undergoing an unrelated umbilical cord blood transplantation.

Exclusion Criteria:

  • Refusal to participate in study.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00179946


Locations
United States, Illinois
Children's Memorial Hospital
Chicago, Illinois, United States, 60622
Sponsors and Collaborators
Ann & Robert H Lurie Children's Hospital of Chicago
Investigators
Principal Investigator: Susanna Rodriguez-Marino, M.D. Ann & Robert H Lurie Children's Hospital of Chicago
  More Information

ClinicalTrials.gov Identifier: NCT00179946     History of Changes
Other Study ID Numbers: BMT 0603 HLA
First Submitted: September 12, 2005
First Posted: September 16, 2005
Last Update Posted: January 15, 2008
Last Verified: January 2008

Additional relevant MeSH terms:
Hematologic Diseases