HLA Matching - Unrelated Umbilical Cord Blood Transplantation
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00179946|
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : January 15, 2008
|Condition or disease||Intervention/treatment|
|Hematologic Diseases||Procedure: HLA typing|
The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.
The study will answer the following questions:
- Is HLA matching beneficial to unrelated UCB transplantation?
- Which HLA loci, HLA-A, B, C, DRB1, or BQB1 is/are important to math, or alternatively to mismatch, to improve graft survival?
- Which HLA loci, HLA-A, B, C, DRB1, or BQB1 mismatches is/are "permissive mismatches" or well tolerated mismatches?
- What level of typing resolution (low, intermediate, or hgh) is required to perform patient/donor H:A matching?
By studying the cells and blood of donors and recipients, we may learn more about improving the tissue matching between unrelated donors and their recipients. Also, we hope to learn if an additional level of matching testing improves the results of the transplant treatment. Increasing knowledge about tissue matching could result in the improved long-term survival of cord blood transplant recipients.
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||Impact of HLA Matching on Outcome in Pediatric Patients Undergoing Unrelated Umbilical Cord Blood Transplantation.|
|Study Start Date :||June 2003|
|Actual Primary Completion Date :||April 2006|
|Actual Study Completion Date :||April 2006|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00179946
|United States, Illinois|
|Children's Memorial Hospital|
|Chicago, Illinois, United States, 60622|
|Principal Investigator:||Susanna Rodriguez-Marino, M.D.||Ann & Robert H Lurie Children's Hospital of Chicago|