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Biomagnetic Signals of Intestinal Ischemia II (SQUID)

This study has been completed.
Sponsor:
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by (Responsible Party):
Alan Bradshaw, Vanderbilt University Medical Center
ClinicalTrials.gov Identifier:
NCT00179036
First received: September 13, 2005
Last updated: April 5, 2017
Last verified: April 2017
  Purpose
The lack of blood flow to the small intestine causes mesenteric ischemia. Using a Superconducting QUantum Interference Device (SQUID) which measures the magnetic field of the small intestine, we are hoping to identify abnormalities without surgical intervention.

Condition
Ischemia

Study Type: Observational
Study Design: Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Biomagnetic Signals of Intestinal Ischemia II

Further study details as provided by Alan Bradshaw, Vanderbilt University Medical Center:

Primary Outcome Measures:
  • To observe a difference in the magnetic activity between the normal and diseased smooth muscle of the small intestine [ Time Frame: 2010 ]

Secondary Outcome Measures:
  • Create mathematical and computer models of electrical activity of smooth muscle [ Time Frame: 2010 ]

Enrollment: 17
Study Start Date: January 2000
Study Completion Date: December 2015
Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Groups/Cohorts
Good blood flow
Group without any ischemia to the small intestine
Poor blood flow
Group with partial ischemia to the small intestine

Detailed Description:
The electrical activity of the small intestine may contain important information that will help us diagnose gastrointestinal diseases. The major impediment to reducing mortality of mesenteric ischemia is the lack of a noninvasive diagnostic test that identifies the syndrome before extensive necrosis occurs. Mesenteric ischemia is caused by the lack of blood flow to the intestine. The Superconducting QUantum Interference Device (SQUID) measures the magnetic field of the intestinal smooth muscle. By comparing normal smooth muscle and that of patients with mesenteric ischemia, the investigators hope to identify abnormal disease states without surgery.
  Eligibility

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
primary care clinic
Criteria

Inclusion Criteria:

  • Normal subjects and those with diagnosed mesenteric ischemia

Exclusion Criteria:

  • Subjects who report a tendency toward claustrophobia
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00179036

Locations
United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Sponsors and Collaborators
Vanderbilt University Medical Center
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
Principal Investigator: William O. Richards, MD Vanderbilt University Medical Center
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Alan Bradshaw, Research Assistant Professor, Vanderbilt University Medical Center
ClinicalTrials.gov Identifier: NCT00179036     History of Changes
Other Study ID Numbers: 060426
R01DK058197 ( U.S. NIH Grant/Contract )
Study First Received: September 13, 2005
Last Updated: April 5, 2017

Keywords provided by Alan Bradshaw, Vanderbilt University Medical Center:
Blood supply
Mesentery

Additional relevant MeSH terms:
Ischemia
Pathologic Processes

ClinicalTrials.gov processed this record on September 21, 2017