Try our beta test site

Biomagnetic Signals of Intestinal Ischemia II (SQUID)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2011 by Vanderbilt University.
Recruitment status was:  Recruiting
National Institutes of Health (NIH)
Information provided by:
Vanderbilt University Identifier:
First received: September 13, 2005
Last updated: June 24, 2011
Last verified: June 2011
The lack of blood flow to the small intestine causes mesenteric ischemia. Using a Superconducting QUantum Interference Device (SQUID) which measures the magnetic field of the small intestine, we are hoping to identify abnormalities without surgical intervention.

Condition Phase
Phase 1

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Biomagnetic Signals of Intestinal Ischemia II

Further study details as provided by Vanderbilt University:

Primary Outcome Measures:
  • To observe a difference in the magnetic activity between the normal and diseased smooth muscle of the small intestine [ Time Frame: 2010 ]

Secondary Outcome Measures:
  • Create mathematical and computer models of electrical activity of smooth muscle [ Time Frame: 2010 ]

Estimated Enrollment: 60
Study Start Date: January 2000
Estimated Study Completion Date: June 2012
Good blood flow
Group without any ischemia to the small intestine
Poor blood flow
Group with partial ischemia to the small intestine

Detailed Description:
The electrical activity of the small intestine may contain important information that will help us diagnose gastrointestinal diseases. The major impediment to reducing mortality of mesenteric ischemia is the lack of a noninvasive diagnostic test that identifies the syndrome before extensive necrosis occurs. Mesenteric ischemia is caused by the lack of blood flow to the intestine. The Superconducting QUantum Interference Device (SQUID) measures the magnetic field of the intestinal smooth muscle. By comparing normal smooth muscle and that of patients with mesenteric ischemia, the investigators hope to identify abnormal disease states without surgery.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
primary care clinic

Inclusion Criteria:

  • Normal subjects and those with diagnosed mesenteric ischemia

Exclusion Criteria:

  • Subjects who report a tendency toward claustrophobia
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00179036

Contact: Alan Bradshaw, PhD 615-322-0705

United States, Tennessee
Vanderbilt University Medical Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: Joan Kaiser, RN    615-343-5821   
Principal Investigator: William O Richards, MD         
Sponsors and Collaborators
Vanderbilt University
National Institutes of Health (NIH)
Principal Investigator: William O. Richards, MD Vanderbilt University Medical Center
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Dr. William O. Richards, Vanderbilt University Identifier: NCT00179036     History of Changes
Other Study ID Numbers: 060426  NIH RO1 DK 58197-05 
Study First Received: September 13, 2005
Last Updated: June 24, 2011

Keywords provided by Vanderbilt University:
Blood supply

Additional relevant MeSH terms:
Pathologic Processes processed this record on February 24, 2017