Vitamin E and Male Infertility
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ClinicalTrials.gov Identifier: NCT00178516 |
Recruitment Status :
Completed
First Posted : September 15, 2005
Last Update Posted : July 30, 2009
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The goal of this study is to determine whether there is a correlation between the levels of Vitamin E in sperm and sperm DNA fragmentation.
Previous research has shown that damage to the DNA in sperm may cause infertility or increase the chances of miscarriage, if the damage is extensive (eg. present in the overwhelming majority of sperm). Some studies suggest that DNA damage can be caused by oxidative stress. Antioxidants, such as Vitamin E, which are present in some foods, can prevent damage to cells from "free radicals", which are naturally present by-products of metabolism. We ask whether there is a correlation between sperm DNA damage and Vitamin E
Condition or disease | Intervention/treatment |
---|---|
Male Infertility | Other: behavior, procedure |
Study Type : | Observational |
Actual Enrollment : | 58 participants |
Observational Model: | Case-Control |
Time Perspective: | Prospective |
Official Title: | Vitamin E and Male Infertility |
Study Start Date : | June 2004 |
Actual Primary Completion Date : | December 2005 |
Actual Study Completion Date : | December 2005 |

- correlate vitamin E levels in spermatozoa with degree of DNA fragmentation in infertile men
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- infertile men with previously abnormal semen analyses.
- Control group: fertile adult males
Exclusion Criteria:
- Proxceed use within 3 months of the start of study.
- Vitamin E supplements with > 45 IU daily

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00178516
United States, New York | |
University of Rochester Medical Center, Department of OB/GYN | |
Rochester, New York, United States, 14642 |
Principal Investigator: | Vivian Lewis, MD | University of Rochester |
Responsible Party: | Vivian LEwis, MD, UNiversity of Rochester Medical Center |
ClinicalTrials.gov Identifier: | NCT00178516 |
Other Study ID Numbers: |
RSRB 10160 |
First Posted: | September 15, 2005 Key Record Dates |
Last Update Posted: | July 30, 2009 |
Last Verified: | July 2009 |
male infertility |
Infertility Infertility, Male |