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Study of Breath-holding as a Means to Reduce Tumor Motion From Breathing

This study has been terminated.
(Drs Okunieff and ODell have left the University of Rochester)
Information provided by (Responsible Party):
University of Rochester Identifier:
First received: September 13, 2005
Last updated: April 18, 2013
Last verified: April 2013
The purpose of this research study is to evaluate typical tumor motion caused by breathing using MRI and can help determine whether simple passive breathing and/or breath-holding could be used for the future treatment of similar lung and liver tumors using radiation therapy radiosurgery techniques.

Condition Intervention
Neoplasm, Metastatic Procedure: MRI with breath-holding

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Feasibility Study for Gated External-Beam Radiotherapy for Patients With Internal, Extra-cranial Tumors

Further study details as provided by University of Rochester:

Primary Outcome Measures:
  • Tumor Motion Related to Breathing as Determined From MRI Images [ Time Frame: 20 - 30 seconds ]
    1. Determine the typical and maximal tumor 3D displacements over the respiratory cycle and how these values vary depending on the tumor location
    2. Determine the reproducibility of target position over multiple breath-holds
    3. Determine the variability across patients in respiratory-derived lesion motion and target position reproducibility over multiple breath-holds

Enrollment: 10
Study Start Date: January 2002
Study Completion Date: January 2011
Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Breath-holding
MRI with breath-holding
Procedure: MRI with breath-holding
Breath holding for diminished tumor motion.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • The patient is enrolled on U8700 RSRB # A Phase II Study For Using Radiosurgery On Limited Metastases Of Breast Cancer or U9700 A Pilot Study For Using Radiosurgery On Limited Metastases.
  • ≥ 18 years of age
  • has given Informed consent

Exclusion Criteria:

-Contraindications for any MRI procedure

  Contacts and Locations
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Please refer to this study by its identifier: NCT00178477

United States, New York
University of Rochester Department of Radiation Oncology
Rochester, New York, United States, 14642
Sponsors and Collaborators
University of Rochester
Principal Investigator: Walter O'Dell, PhD University of Rochester
  More Information

Responsible Party: University of Rochester Identifier: NCT00178477     History of Changes
Other Study ID Numbers: URCC 3701
Study First Received: September 13, 2005
Results First Received: August 12, 2011
Last Updated: April 18, 2013 processed this record on August 18, 2017