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Effects of Comorbid Personality Disorder on the Treatment of Bipolar I Disorder

This study has been completed.
Information provided by:
University of Pittsburgh Identifier:
First received: September 13, 2005
Last updated: June 21, 2013
Last verified: June 2013
This study will examine the impact of comorbid personality disorder on the outcome of treatment among patients with bipolar I disorder.

Condition Intervention Phase
Bipolar I Disorder
Borderline Personality Disorder
Behavioral: Interpersonal Social Rhythm Therapy (IPSRT)
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Treatment of Primary Mood Disorders in the Comorbidly Ill

Resource links provided by NLM:

Further study details as provided by University of Pittsburgh:

Primary Outcome Measures:
  • Hamilton Rating Scale for Depression (HRSD-25)

Secondary Outcome Measures:
  • Raskin Severity of Depression and Mania Scales

Estimated Enrollment: 13
Study Start Date: August 1997
Estimated Study Completion Date: August 2002
Detailed Description:

The major aim of this proposal is to examine the impact of comorbid personality disorder on the outcome of treatment among patients with bipolar I disorder.

The specific aims are to create a research and supervisory team and to identify potential moderators of treatment response and mediators of outcome over the course of treatment.

Members of the team will meet weekly to begin a treatment development process for enhancing Interpersonal Social Rhythm Therapy (IPSRT) for these patients. Additional assessment measures will be utilized to examine the proposed mediators and moderators of treatment.


Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Bipolar I Disorder with Comorbid Borderline Personality Disorder, currently manic or depressed

Exclusion Criteria:

  • Unstable Medical illness
  Contacts and Locations
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Please refer to this study by its identifier: NCT00178061

United States, Pennsylvania
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
University of Pittsburgh
Principal Investigator: Ellen Frank University of Pittsburgh
  More Information Identifier: NCT00178061     History of Changes
Other Study ID Numbers: 970843-0109
Study First Received: September 13, 2005
Last Updated: June 21, 2013

Additional relevant MeSH terms:
Borderline Personality Disorder
Personality Disorders
Pathologic Processes
Mental Disorders processed this record on May 24, 2017