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Topical Hydromorphone for Wound Healing

This study has been terminated.
(No funding available.)
Information provided by:
University of Minnesota - Clinical and Translational Science Institute Identifier:
First received: September 13, 2005
Last updated: February 26, 2010
Last verified: February 2010
The hypothesis is that topical opioids will hasten wound healing in humans.

Condition Intervention Phase
Wound Healing
Drug: hydromorphone
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single Blind
Primary Purpose: Treatment
Official Title: Topical Hydromorphone for Wound Healing

Resource links provided by NLM:

Further study details as provided by University of Minnesota - Clinical and Translational Science Institute:

Primary Outcome Measures:
  • Healing rates and microvessel density will be compared statistically for the control-ointment versus hydromorphone-ointment subjects.

Estimated Enrollment: 50
Study Start Date: October 2003
Study Completion Date: May 2007
Detailed Description:
This is based on our published data that morphine is a powerful stimulant of angiogenesis and our preclinical study of wounds in rats which demonstrate that topical opioids (morphine, hydromorphone and fentanyl) hasten healing of punch biopsy wounds. This study will focus on hydromorphone which was more powerful than morphine as a wound-healer in the rat study.

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Self-identified as normal, healthy volunteers age 18-65.

Exclusion Criteria:

  • Known bleeding disorder.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00177060

United States, Minnesota
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Sponsors and Collaborators
Hordinsky, Maria K., MD
Principal Investigator: Maria Hordinsky, MD University of Minnesota - Clinical and Translational Science Institute
Principal Investigator: Robert Hebbel, MD University of Minnesota - Clinical and Translational Science Institute
  More Information Identifier: NCT00177060     History of Changes
Other Study ID Numbers: 0308M50994
Study First Received: September 13, 2005
Last Updated: February 26, 2010

Additional relevant MeSH terms:
Wounds and Injuries
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents processed this record on April 26, 2017