Topical Hydromorphone for Wound Healing
The hypothesis is that topical opioids will hasten wound healing in humans.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind
Primary Purpose: Treatment
|Official Title:||Topical Hydromorphone for Wound Healing|
- Healing rates and microvessel density will be compared statistically for the control-ointment versus hydromorphone-ointment subjects.
|Study Start Date:||October 2003|
|Study Completion Date:||May 2007|
This is based on our published data that morphine is a powerful stimulant of angiogenesis and our preclinical study of wounds in rats which demonstrate that topical opioids (morphine, hydromorphone and fentanyl) hasten healing of punch biopsy wounds. This study will focus on hydromorphone which was more powerful than morphine as a wound-healer in the rat study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00177060
|United States, Minnesota|
|University of Minnesota|
|Minneapolis, Minnesota, United States, 55455|
|Principal Investigator:||Maria Hordinsky, MD||University of Minnesota - Clinical and Translational Science Institute|
|Principal Investigator:||Robert Hebbel, MD||University of Minnesota - Clinical and Translational Science Institute|