Impact of Exercise Training on Exercise Capacity in Patients With Severe Chronic Heart Failure
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|ClinicalTrials.gov Identifier: NCT00176384|
Recruitment Status : Completed
First Posted : September 15, 2005
Last Update Posted : August 1, 2007
Patients with heart failure are limited in their exercise capacity due to skeletal muscle alteration and an impairment of peripheral perfusion. Regular physical exercise training has been shown to partially correct these peripheral maladaptations in patients with stable heart failure, which was associated with an improvement in exercise capacity. However, it is unknown so far, whether regular physical activity also exerts beneficial effects in patients with severe chronic heart failure.
Aim of the trial is therefore to assess the effects of aerobic exercise training on exercise capacity, muscle maladaptations and peripheral perfusion in patients with severe chronic heart failure according to NYHA class III b.
|Condition or disease||Intervention/treatment||Phase|
|Heart Failure||Behavioral: Aerobic endurance exercise training (ergometer)||Phase 2|
A total of 36 patients with severe chronic heart failure are prospectively randomized to either 3 months of aerobic ergometer training or a sedentary control group.
Before and after the intervention period maximal exercise capacity is assessed by ergospirometry, endothelial function is determined by high-resolution A-mode ultrasound, and muscle mass is determined by CT. Skeletal muscle biopsies are obtained at begin and after 3 months and are analyzed for markers of muscle catabolism/anabolism.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||36 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Impact of Three Months of Aerobic Exercise Training on Exercise Capacity and Peripheral Maladaptations in Patients With Severe Chronic Heart Failure (NYHA III b)|
|Study Start Date :||March 2003|
|Study Completion Date :||December 2006|
- Peak oxygen uptake
- Endothelial function
- Skeletal muscle mass
- Markers of muscle anabolism / catabolism
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00176384
|University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology|
|Leipzig, Saxony, Germany, 04289|
|Principal Investigator:||Rainer P Hambrecht, MD||University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology, Leipzig, Germany|