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Impact of Exercise Training on Endothelial Function in CAD

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ClinicalTrials.gov Identifier: NCT00176345
Recruitment Status : Unknown
Verified September 2005 by University of Leipzig.
Recruitment status was:  Recruiting
First Posted : September 15, 2005
Last Update Posted : September 15, 2005
Sponsor:
Information provided by:

Study Description
Brief Summary:

Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promoting a vasodilatory respone. Regular physical exercise training results in an improvement of endothelial function in patients with CAD. These positive effects were partially attributed to an increased expression of endothelial NO synthase (eNOS) and cyclooxygenase (COX) as a result of the training intervention.

Aim of this trial is therefore to determine, whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent.


Condition or disease Intervention/treatment Phase
Coronary Artery Disease Behavioral: Exercise Training Phase 2

Detailed Description:

A total of 20 patients with stable coronary artery disease are prospectively randomized to 4 weeks of exercise training or sedentary lifestyle.

Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound.


Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Educational/Counseling/Training
Official Title: Impact of Exercise Training on Bradykinin-Mediated Endothelial Function in Patients With Coronary Artery Disease
Study Start Date : January 2001

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions


Outcome Measures

Primary Outcome Measures :
  1. Endothelial function

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • stable CAD
  • male gender

Exclusion Criteria:

  • insulin-dependent diabetes mellitus
  • significant valvular heart disease
  • smoking
  • exercise-induced myocardial ischemia
  • conditions prohibiting exercise training
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00176345


Contacts
Contact: Rainer P Hambrecht, MD ++49-341 865 ext 1428 hamr@medizin.uni-leipzig.de
Contact: Sandra Erbs, MD ++49-341 865 ext 1428 Sandra.Erbs@medizin.uni-leipzig.de

Locations
Germany
University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology Recruiting
Leipzig, Saxony, Germany, 04289
Contact: Rainer P Hambrecht, MD    ++49-341-865 ext 1428    hamr@medizin.uni-leipzig.de   
Contact: Sandra Erbs, MD    ++49-341-865 ext 1428    Sandra.Erbs@medizin.uni-leipzig.de   
Principal Investigator: Rainer P Hambrecht, MD         
Sponsors and Collaborators
University of Leipzig
Investigators
Principal Investigator: Rainer P Hambrecht, MD University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology
More Information

ClinicalTrials.gov Identifier: NCT00176345     History of Changes
Other Study ID Numbers: 639/97
157/02
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: September 15, 2005
Last Verified: September 2005

Keywords provided by University of Leipzig:
exercise training
endothelial function

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases