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Impact of Exercise Training on Endothelial Function in CAD

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2005 by University of Leipzig.
Recruitment status was:  Recruiting
Information provided by:
University of Leipzig Identifier:
First received: September 11, 2005
Last updated: NA
Last verified: September 2005
History: No changes posted

Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promoting a vasodilatory respone. Regular physical exercise training results in an improvement of endothelial function in patients with CAD. These positive effects were partially attributed to an increased expression of endothelial NO synthase (eNOS) and cyclooxygenase (COX) as a result of the training intervention.

Aim of this trial is therefore to determine, whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent.

Condition Intervention Phase
Coronary Artery Disease
Behavioral: Exercise Training
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Educational/Counseling/Training
Official Title: Impact of Exercise Training on Bradykinin-Mediated Endothelial Function in Patients With Coronary Artery Disease

Resource links provided by NLM:

Further study details as provided by University of Leipzig:

Primary Outcome Measures:
  • Endothelial function

Estimated Enrollment: 20
Study Start Date: January 2001
Detailed Description:

A total of 20 patients with stable coronary artery disease are prospectively randomized to 4 weeks of exercise training or sedentary lifestyle.

Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound.


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • stable CAD
  • male gender

Exclusion Criteria:

  • insulin-dependent diabetes mellitus
  • significant valvular heart disease
  • smoking
  • exercise-induced myocardial ischemia
  • conditions prohibiting exercise training
  Contacts and Locations
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Please refer to this study by its identifier: NCT00176345

Contact: Rainer P Hambrecht, MD ++49-341 865 ext 1428
Contact: Sandra Erbs, MD ++49-341 865 ext 1428

University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology Recruiting
Leipzig, Saxony, Germany, 04289
Contact: Rainer P Hambrecht, MD    ++49-341-865 ext 1428   
Contact: Sandra Erbs, MD    ++49-341-865 ext 1428   
Principal Investigator: Rainer P Hambrecht, MD         
Sponsors and Collaborators
University of Leipzig
Principal Investigator: Rainer P Hambrecht, MD University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology
  More Information Identifier: NCT00176345     History of Changes
Other Study ID Numbers: 639/97
Study First Received: September 11, 2005
Last Updated: September 11, 2005

Keywords provided by University of Leipzig:
exercise training
endothelial function

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases processed this record on May 25, 2017