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Risk Indicators in Patients With Ventricular Fibrillation During Acute Myocardial Infarction

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ClinicalTrials.gov Identifier: NCT00175942
Recruitment Status : Unknown
Verified May 2005 by Heidelberg University.
Recruitment status was:  Recruiting
First Posted : September 15, 2005
Last Update Posted : September 15, 2005
Sponsor:
Information provided by:
Heidelberg University

Brief Summary:
Sudden cardiac death is in most cases triggered by ischemia-related ventricular tachyarrhythmias and accounts for 50% of deaths from cardiovascular disease in developed countries. Chronic elevation of indicators of coagulation activation has been found in patients with coronary heart disease , but a role of coagulation activation and proinflammatory state as a potential risk factor for ventricular fibrillation (VF) during acute myocardial infarction has not been investigated.

Condition or disease
Acute Myocardial Infarction Sudden Cardiac Death

Detailed Description:
Sudden cardiac death (SCD) is in most cases triggered by ischemia-related ventricular arrhythmias and is responsible for 50% of the mortality from cardiovascular disease in developed countries (1). Chronic elevation of indicators of coagulation activation and inflammation has been found in patients with coronary heart disease and may contribute to vasculatory disorders probably contributing to the development of arrhythmogenesis. However, the role of coagulation activation as a potential risk factor for ventricular fibrillation during acute myocardial infarction has not been investigated yet.

Study Type : Observational
Enrollment : 300 participants
Observational Model: Defined Population
Time Perspective: Longitudinal
Time Perspective: Retrospective/Prospective
Official Title: Indicators of Coagulation Activation and Inflammation Contributing to Ventricular Fibrillation Complicating Acute Myocardial Infarction
Study Start Date : February 2003

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack
U.S. FDA Resources





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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

ST-elevation myocardial infarction ventricular fibrillation during acute MI

Exclusion Criteria:

NSTEMI coagulation disorders, e.g.intake of coumadin


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00175942


Contacts
Contact: Elif Elmas, MD, Dr. 00496213833988
Contact: Martina Brückmann, MD, Dr.

Locations
Germany
University Hospital of Mannheim, University of Heidelberg Recruiting
Mannheim, Germany, 68167
Sub-Investigator: Elif Elmas, MD. Dr         
Sponsors and Collaborators
Heidelberg University
Investigators
Principal Investigator: Carl E. Dempfle, Prof.Dr. University Hospital of Mannheim, University of Heidelberg

ClinicalTrials.gov Identifier: NCT00175942     History of Changes
Other Study ID Numbers: 0229.3
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: September 15, 2005
Last Verified: May 2005

Keywords provided by Heidelberg University:
acute myocardial infarction
ventricular fibrillation
coagulation
inflammation

Additional relevant MeSH terms:
Infarction
Myocardial Infarction
Death
Death, Sudden, Cardiac
Ventricular Fibrillation
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Heart Arrest
Death, Sudden
Arrhythmias, Cardiac