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Detection of Early Lung Cancer by Serum Protein Expression Profiling

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2011 by University of British Columbia.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
University of British Columbia Identifier:
First received: September 13, 2005
Last updated: November 15, 2011
Last verified: November 2011
Promising new technology exists to examine small proteins that are shed by cancers into the blood stream. The purpose of this study is to see if there are differences in the proteins and protein levels in blood from individuals with early stage lung cancer compared to healthy adults.

Non-small Cell Lung Cancer

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Differences in SELDI Produced Serum Protein Profiles of Non-small Cell Lung Cancer Patients Compared to Healthy Heavy Smoking Adults

Resource links provided by NLM:

Further study details as provided by University of British Columbia:

Estimated Enrollment: 220
Study Start Date: May 2005
Estimated Study Completion Date: December 2011
Detailed Description:
A prospective longitudinal patient-based pilot study is proposed whereby surfaced enhanced laser desorption ionization time-of-flight mass spectroscopy (SELDI-TOF-MS) will be used to discover and validate serum proteomic expression profiles diagnostic of early lung cancer. A unique approach will be used to compare the serum proteomic expression profiles of patients with non-small cell lung cancer compared to healthy heavy smoking adults, as well as differences before and after anatomic pulmonary resection with curative intent. Discriminatory proteins will be selected by their differential expression before compared to after surgical removal of a tumor. The protein profile of blood obtained from the draining pulmonary vein at the time of resection will be used to identify materials potentially shed by the tumor that may serve as biomarkers in peripheral blood. The serum samples will be used to develop a training data set and then a test set for validation using a class prediction model. Candidate proteomic patterns will then serve as a basis for a larger prospective multi-centre clinical trial.

Ages Eligible for Study:   45 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients with non-small cell lung cancer and healthy heavy smoking adults.

Inclusion Criteria:

  • Presence of early stage non-small cell lung cancer
  • Elective surgical resection of lung lesion at Vancouver General Hospital (VGH)
  • No preoperative chemoradiation therapy
  • No previous cancer
  • Ability to provide informed consent
  Contacts and Locations
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Please refer to this study by its identifier: NCT00175578

Contact: Jennifer Rattenbury 604-875-4111 ext 62183

Canada, British Columbia
Vancouver General Hospital BC Cancer Agency Recruiting
Vancouver, British Columbia, Canada
Contact: Jennifer Rattenbury    604-875-4111 ext 62183      
Principal Investigator: John Yee, MD         
Sponsors and Collaborators
University of British Columbia
Principal Investigator: John Yee, MD University of British Columbia
  More Information

Responsible Party: University of British Columbia Identifier: NCT00175578     History of Changes
Other Study ID Numbers: C04-0640
Study First Received: September 13, 2005
Last Updated: November 15, 2011

Keywords provided by University of British Columbia:
Early stage (0/I) non-small cell lung cancer

Additional relevant MeSH terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms processed this record on May 25, 2017