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Feasibility Study: The Effect of Prazosin for Nighttime Symptoms of Civilian PTSD

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2005 by Rainier Associates.
Recruitment status was:  Active, not recruiting
Information provided by:
Rainier Associates Identifier:
First received: September 9, 2005
Last updated: September 7, 2006
Last verified: September 2005
Investigating the effect of prazosin for nighttime symptoms of civilian Posttraumatic Stress Disorder.

Condition Intervention
Stress Disorders, Post-Traumatic Drug: prazosin

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: The Effect of Prazosin for Nighttime Symptoms of Civilian PTSD

Resource links provided by NLM:

Further study details as provided by Rainier Associates:

Primary Outcome Measures:
  • Sleep time
  • REM sleep time
  • Nightmare frequency
  • CGI

Secondary Outcome Measures:
  • Distressed Awakenings frequency
  • PCL-C

Estimated Enrollment: 20
Study Start Date: November 2003
Estimated Study Completion Date: November 2005
Detailed Description:
Each subject will receive prazosin and placebo trials, the order randomized. Day and nighttime symptoms will be monitored.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • must meet DSM-IV criterion for PTSD

Exclusion Criteria:

  • Must not have untreated sleep apnea
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00174551

United States, Washington
Fletcher B. Taylor
Tacoma, Washington, United States, 98467
Sponsors and Collaborators
Rainier Associates
Principal Investigator: Fletcher B Taylor, M.D. Rainier Associates
  More Information Identifier: NCT00174551     History of Changes
Other Study ID Numbers: 20031050
Study First Received: September 9, 2005
Last Updated: September 7, 2006

Additional relevant MeSH terms:
Stress Disorders, Post-Traumatic
Stress Disorders, Traumatic
Trauma and Stressor Related Disorders
Mental Disorders
Antihypertensive Agents
Adrenergic alpha-1 Receptor Antagonists
Adrenergic alpha-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs processed this record on August 21, 2017