Diagnosis of Active Tuberculosis by ELISPOT

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00174083
Recruitment Status : Unknown
Verified July 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 15, 2005
Last Update Posted : September 15, 2005
Information provided by:
National Taiwan University Hospital

Brief Summary:
Recent studies revealed that the ex vivo enzyme-linked immunospot (ELISPOT) assay for gamma interferon is a specific method for contact tracing of Mycobacterium tuberculosis infection. However, its use in endemic area and bacillus Calmette-Guérin (BCG)-vaccinated hosts has not been proved. We hypothesize that the TB-ELISPOT assay can be a rapid and accurate diagnostic tool for active tuberculosis in clinical suspects in Taiwan.

Condition or disease

Study Type : Observational
Enrollment : 200 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Diagnosis of Active Tuberculosis in Endemic Area by Using Enzyme-Linked Immunospot Assay for Gamma-Interferon
Study Start Date : August 2005
Study Completion Date : December 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Tuberculosis
Drug Information available for: Interferon

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients who present with fever or respiratory symptoms (cough, dyspnea, or hemoptysis) lasting for ≥ 2 weeks and have compatible radiographic findings were considered clinical suspects of TB.

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00174083

Contact: Jann-Yuan Wang, MD 886-2-23562905

National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Jann-Yuan Wang, MD    886-2-23562905   
Contact: Li-Na Lee, PhD    886-2-23563905   
Principal Investigator: Jann-Yuan Wang, MD         
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Jann-Yuan Wang, MD physician

Publications: Identifier: NCT00174083     History of Changes
Other Study ID Numbers: 9461700717
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: September 15, 2005
Last Verified: July 2005

Keywords provided by National Taiwan University Hospital:
Tuberculosis, TB-ELISPOT, active tuberculosis latent infection interferon

Additional relevant MeSH terms:
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections
Antineoplastic Agents
Antiviral Agents
Anti-Infective Agents