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Induction of Cytokines in Human Monocytes by SARS-CoV in Adults and Children

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
National Science Council, Taiwan
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 12, 2005
Last updated: November 30, 2007
Last verified: August 2005

Severe acute respiratory syndrome (SARS) is a new emerging infectious disease. Its pathogen is a newly discovered coronavirus (SARS-CoV). The clinical course can be classified to 3 stages: viral replication phase, hyperimmune reactive phase, and pulmonary destruction phase. Human monocyte plays a critical role in the initiation of immune response in defending the intracellular pathogens (eg viruses). Monocytes can engulf viruses and present the viral antigens in the major histocompatibility (MHC) molecule to the cell surface to initiate T lymphocyte response. Monocytes also secrete various cytokines to modulate immune response. SARS-CoV is a mutant of animal virus to cause human disease and is able to cause unusual severe respiratory illness. It is suggested the unusual severe disease is due to the intense immune reaction.

The investigators will harvest human monocytes from healthy adult and children blood donors. Monocytes would be cultured and infected by SARS-CoV. The change of viral load is monitored after infection. Cytokines secreted by monocytes after infection are also measured. The difference of monocyte cytokine secretion is compared between adults and children. The study is to verify the SARS-CoV infectivity of human monocytes and prove the unusual severity caused by SARS-CoV is related to viral-induced dysregulation of cytokine responses. The results may also clarify why adults tend to have a more severe illness compared with children.


Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Induction of Cytokines in Human Monocytes by SARS-CoV in Adults and Children

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 10
Study Start Date: January 2005
Estimated Study Completion Date: September 2005

Ages Eligible for Study:   2 Years to 50 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy adults aged 20 to 50 years old
  • Healthy children aged 2 to 5 years old
  Contacts and Locations
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Please refer to this study by its identifier: NCT00173563

National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Luan-Yin Chang, MD, PhD    886-2-23123456 ext 3245   
Contact: Pei-Lan Shao, MD    886-2-23123456 ext 2394   
Sponsors and Collaborators
National Taiwan University Hospital
National Science Council, Taiwan
Principal Investigator: Luan-Yin Chang, MD, PhD Department of pediatrics, National Taiwan University Hospital
  More Information Identifier: NCT00173563     History of Changes
Other Study ID Numbers: 9461700731
Study First Received: September 12, 2005
Last Updated: November 30, 2007

Keywords provided by National Taiwan University Hospital:
Immunology processed this record on September 21, 2017