PharmacoEconomic Assessment IRESSA® in the Treatment of Non-Small-Cell Lung Cancer (NSCLC)
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|ClinicalTrials.gov Identifier: NCT00173524|
Recruitment Status : Unknown
Verified April 2009 by National Taiwan University Hospital.
Recruitment status was: Active, not recruiting
First Posted : September 15, 2005
Last Update Posted : May 19, 2009
|Condition or disease||Intervention/treatment||Phase|
|Non-Small Cell Lung Cancer||Behavioral: PharmacoEconomic Assessment||Phase 4|
Patients with late-stage NSCLC are often symptomatic, with specific pulmonary problems (eg, cough, breathlessness, hemoptysis) and general symptoms (eg. fatigue, weight loss) that can cause extreme distress to the patient. Therefore, improvements in disease-related symptoms and quality of life (QoL) are the key desired outcomes of medical management.7 Effective, palliative, low-toxicity with reasonable treatment cost for patients with advanced NSCLC are needed. Recently, more and more countries consider evidence of economic value along with clinical efficacy.
The epidermal growth factor receptor (EGFR) is a promising target for anticancer therapy because it is expressed or highly expressed in a variety of tumors, including NSCLC. 8,9 Furthermore, high levels of EGFR expression have been associated with a poor prognosis in lung cancer patients in several studies. 10-12 EGFR-targeted cancer therapies are currently being developed; strategies include inhibition of the intracellular tyrosine kinase domain of the receptor by small molecules such as gefitinib (Iressa [ZD1839]; AstraZeneca, Wilmington, DE).13 Iressa is an orally active, selective EGFR tyrosine kinase inhibitor that blocks signal transduction pathways implicated in the proliferation and survival of cancer cells.
|Study Type :||Observational|
|Estimated Enrollment :||200 participants|
|Official Title:||PharmacoEconomic Assessment IRESSA® in the Treatment of Non-Small-Cell Lung Cancer (NSCLC) : A Cost-Effectiveness Analysis and Cost-Utility Analysis|
|Study Start Date :||September 2005|
|Estimated Study Completion Date :||September 2005|
Behavioral: PharmacoEconomic Assessment
- The objective of this PE study is to evaluate the cost- effectiveness analysis and cost-utility analysis of IRESSA® as first line treatment of NSCLC from the society perspective, comparing to existing first line platinum-based regimen chemotherapy. [ Time Frame: 2-3 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00173524
|Department of Oncology, National Taiwan University Hospital|
|Principal Investigator:||Lin Zone-Zhe, M.D.||Department of Oncology , National Taiwan University Hospital|
|Study Chair:||Cheng Ann-Lii, M.D.,Ph.D.||Department of Oncology , National Taiwan University Hospital|