The Study of Infection and Cell Inflammation in Peritoneal Dialysate

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2005 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 12, 2005
Last updated: November 23, 2005
Last verified: June 2005

A progressive decline of plasma triggering receptor expressed on myeloid cells-1 (TREM-1) concentration indicates a favorable clinical evolution during the recovery phase of sepsis. The expression of TREM-1 in dialysate of peritoneal dialysis patients was not yet documented. We will collect the dialysate of peritonitis in peritoenal dialysis patients and analyze the time serial change.

Kidney Failure

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 100
Study Start Date: June 2005
Estimated Study Completion Date: June 2009
Detailed Description:

The triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily, and its expression is upregulated on phagocytic cells in the presence of bacteria or fungi (1). Several experiments by Bouchon and colleagues showed that TREM-1 mediates the acute inflammatory response to microbial products. Human tissues infected with bacteria are infiltrated with neutrophils and macrophages that express high levels of TREM-1. Conversely, TREM-1 is only weakly expressed in samples from patients with noninfectious inflammatory disorders. In addition, TREM-1 is shed from the membrane of activated phagocytes and can be found in a soluble form in body fluids. The presence of a soluble form of TREM-1 in samples of bronchoalveolar lavage fluid from mechanically ventilated patients has been shown to be a good indicator of infectious pneumonia. During sepsis, a progressive decline of plasma sTREM-1 concentration indicates a favorable clinical evolution during the recovery phase of sepsis. In addition, baseline sTREM-1 level may prove useful in predicting outcome of septic patients. We will collect the dialysate of peritonitis in peritoneal dialysis patients and analyze the time serials change.


Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

peritoneal dialysis patients, dialysis period for more than 3 months.

Exclusion Criteria:

age younger than 18 years old, Pregnant or lactating women. (Pre-menopause women, capable of bearing children will undergo pregnancy test)

  Contacts and Locations
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Please refer to this study by its identifier: NCT00173485

Contact: Vin-cent Wu, MD 886-2-2356-2000

National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Vincent Wu, MD    886-2-2356-2000   
Sponsors and Collaborators
National Taiwan University Hospital
Study Chair: Kwan-Dun Wu, MD, PhD National Taiwan University
  More Information

Publications: Identifier: NCT00173485     History of Changes
Other Study ID Numbers: 9461700636
Study First Received: September 12, 2005
Last Updated: November 23, 2005
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
peritonitis, peritoneal dialysis, dialysate

Additional relevant MeSH terms:
Renal Insufficiency
Digestive System Diseases
Intraabdominal Infections
Kidney Diseases
Peritoneal Diseases
Urologic Diseases processed this record on October 06, 2015