Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00173459
Recruitment Status : Completed
First Posted : September 15, 2005
Last Update Posted : September 15, 2005
Information provided by:
National Taiwan University Hospital

Brief Summary:
Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus (SARS-CoV). The major clinical features of SARS include fever, dyspnea, lymphopenia, and a rapid progression of pulmonary infiltrates on chest radiologic images. The SARS-related deaths have resulted mainly from pulmonary complications, including progressive respiratory failure due to alveolar damage and acute respiratory distress syndrome (ARDS). Pathological changes in SARS suggest that SARS sequelae such as infiltration of PMN in lung tissue, multiple organ dysfunction and ARDS have been associated with cytokines and chemokine dysregulation. Some patients still manifested lung injury at a time when the viral load was falling also supports the immune nature of the lung damage. We therefore undertook an analysis of dynamic production of cytokine/chemokines in SARS patients with an initial normal chest radiograph in order to improve understanding of disease pathogenesis and improve patient management.

Condition or disease

Study Type : Observational
Observational Model: Case Control
Time Perspective: Longitudinal
Time Perspective: Retrospective

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Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • SARS group: Patients with SARS

Exclusion Criteria:

  • Hospital acquired pneumonia

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Please refer to this study by its identifier (NCT number): NCT00173459

Sponsors and Collaborators
National Taiwan University Hospital
Study Chair: Jung-Yien Chien, MD NTUH Identifier: NCT00173459     History of Changes
Other Study ID Numbers: 9461700671
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: September 15, 2005
Last Verified: July 2004

Additional relevant MeSH terms:
Severe Acute Respiratory Syndrome
Coronavirus Infections
Coronaviridae Infections
Nidovirales Infections
RNA Virus Infections
Virus Diseases
Respiratory Tract Infections
Respiratory Tract Diseases