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Congenital or Idiopathic Complete Right Bundle Branch Block: Physiological Significance and Molecular Characterization

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00173342
First Posted: September 15, 2005
Last Update Posted: December 9, 2005
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Taiwan University Hospital
  Purpose
This study is to determine 1) the incidence of altered right bundle conduction, including CRBBB, IRBBB or rsR’ pattern in the Taipei city based on the school survey databank from 1999 to 2002, 2) the associated cardiac lesions, 3) clinical presentations relevant to the altered right bundle conduction, 4) the association with QTc prolongation and dispersion and HRV from a 5-minutes recording. Finally, molecular characterization for those with CRBBB or Brugada pattern EKG, especially those with positive family history will be studied.

Condition
Bundle-Branch Block

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Congenital or Idiopathic Complete Right Bundle Branch Block: Physiological Significance and Molecular Characterization

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 50
Study Start Date: June 2005
Detailed Description:

The EKG pattern and medical records from the school survey from 1999 to 2002 in Taipei city will be reviewed, and the basic data of those with CRBBB, IRBBB and rsR’ pattern will be recorded. Interview will be made and the echocardiographic measurements will be performed to identify associated cardiac defects. EKG parameters and QT, QTc, QT dispersion, QTc dispersion and HRV parameters will be obtained from a semi-automated system. Time domain and frequency domain measures will be calculated and expressed as SDNN, triangular index, SDNN index, total power, low frequency power and high frequency power. Mutational analysis and DNA sequencing will be conducted in those with CRBBB or Brugada pattern EKG, especially those with positive family history.

Based on these data, the clinical significance of altered bundle branch conduction identified from a school survey may be defined. For those with isolated CRBBB or IRBBB, the adjunctive value of HRV and QT parameters will determined the high risk group, and 24 hour Holter recording and Treadmill exercise test will then perform in these patients to define association with ventricular arrhythmia.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   8 Years to 25 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ECG showed right bundle branch block

Exclusion Criteria:

  • can't tolerate Treadmill ECG study
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00173342


Contacts
Contact: Mei-Hwan Wu, MD, PhD 886-2-23123456 ext 5126 mhwu@ha.mc.ntu.edu.tw
Contact: Shuenn-Nan Chiu, MD 886-2-23123456 ext 5126 michael@ha.mc.ntu.edu.tw

Locations
Taiwan
Department of Pediatrics, National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Mei-Hwan Wu, MD, PhD    886-2-23123456 ext 5126    mhwu@ha.mc.ntu.edu.tw   
Contact: Shuenn-Nan Chiu, MD    886-2-23123456 ext 5126    michael@ha.mc.ntu.edu.tw   
Pediatric Department, National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Shuenn-Nan Chiu, MD    886-2-23123456 ext 5126    michael@ha.mc.ntu.edu.tw   
Contact: Mei-Hwan Wu, MD, PhD    886-2-23123456 ext 5126    mhwu@ha.mc.ntu.edu.tw   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Study Chair: Mei-Hwan Wu, MD, PhD National Taiwan University Hospital
  More Information

ClinicalTrials.gov Identifier: NCT00173342     History of Changes
Other Study ID Numbers: 9461700620
First Submitted: September 12, 2005
First Posted: September 15, 2005
Last Update Posted: December 9, 2005
Last Verified: June 2005

Keywords provided by National Taiwan University Hospital:
Right bundle branch block
Electrocardiography
Ion channel

Additional relevant MeSH terms:
Bundle-Branch Block
Heart Block
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes