The Difference in Presentation Level of Variant Receptors in Female Breast Tissue in Macromastia and Micromastia
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|ClinicalTrials.gov Identifier: NCT00173251|
Recruitment Status : Unknown
Verified June 2005 by National Taiwan University Hospital.
Recruitment status was: Not yet recruiting
First Posted : September 15, 2005
Last Update Posted : September 15, 2005
|Condition or disease||Intervention/treatment||Phase|
|Aging||Procedure: obtain surgical specimen for analysis||Phase 1|
Large breasts cause neck and back pain, irritating grooves, cut in the skin of the shoulders by the pressure of brassiere straps, breast pain, and maceration and dermatoses in the inframammary region. From a psychological point of view, excessively large breasts can be troublesome focus of embarrassment for the teenager as well as the woman in her senior years. Unilateral hypertrophy with asymmetry heightens embarrassment. Thus, patients seek to reduce the size of their breasts.
In the human female, variant receptors were detected in epithelial cells in normal breast tissue, benign breast lesions, breast carcinoma tissue, and breast cancer cell lines2-11. The cause of the difference in breast development status is still unclear. Abnormalities at the tissue receptor level may be important in the pathophysiology of macromastia. This study aimed to make clear the difference in variant receptor levels between breast hypertrophy patients and macromastia ones by examining the receptor levels in breast tissue. Then, we could explore the possible etiology of mammary hypertrophy and macromastia.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||60 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Study Start Date :||January 2006|
|Study Completion Date :||August 2006|
- difference in receptor expression level
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00173251
|Contact: Hao-Chih Tai, M.D.||886-2-23123456 ext email@example.com|
|Principal Investigator:||Hao-Chih Tai, M.D.||National Taiwan University Hospital|