The Study of Human Atherosclerosis by Polarization-Sensitive Optical Coherence Tomography
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|ClinicalTrials.gov Identifier: NCT00173238|
Recruitment Status : Unknown
Verified June 2005 by National Taiwan University Hospital.
Recruitment status was: Recruiting
First Posted : September 15, 2005
Last Update Posted : December 21, 2005
Atherosclerosis is unquestionably the leading cause of morbidity and mortality in developed countries, and the world-wide importance of acute vascular syndromes is increasing. Rupture of atherosclerotic plaque has been identified as the proximate event in the majority of cases of acute ischemic syndromes. Therefore, modalities capable of characterizing the atherosclerotic lesion may be helpful in understanding its natural history and detecting lesions with high risk for acute events.
Optical coherence tomography (OCT) is a powerful tool capable of tomographic imaging based on low coherence interferometry. It is analogous to ultrasound imaging except that it uses infrared light instead of sound. Polarization-sensitive optical coherence tomography (PS-OCT) combines the advantages of OCT with additional image contrast of the sample. The added contrast is based on the ability of PS-OCT to detect the birefringent properties of a sample (phase retardation and fast-axis orientation) simultaneously.
The goals of this project are: 1) to examine whether PS-OCT is an acceptable tool for the characterization of typical plaque constituents; and 2) to explain the correlation between birefringence and forming or rupture of a plaque; and 3) to establish a quantitative PS-OCT image criteria for atherosclerotic plaque characterization in vitro.
|Condition or disease|
|Pathological Conditions, Anatomical|
|Study Type :||Observational|
|Estimated Enrollment :||5 participants|
|Observational Model:||Case Control|
|Study Start Date :||June 2005|
|Estimated Study Completion Date :||June 2008|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00173238
|Contact: Nai-Kuan Chou, MD.,PhD||886-2-23123456 ext email@example.com|
|National Taiwan University Hospital||Recruiting|
|Taipei, Taiwan, 100|
|Contact: Nai-Kuan Chou, MD.,PhD 886-2-23123456 ext 5066 firstname.lastname@example.org|
|Principal Investigator: Nai-Kuan Chou, MD.,PhD|
|Principal Investigator:||Nai-Kuan Chou, MD.,PhD||National Taiwan University Hospital,Taipei.Taiwan|