The Role of Insulin Resistance in PCOS
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|ClinicalTrials.gov Identifier: NCT00173043|
Recruitment Status : Unknown
Verified October 2004 by National Taiwan University Hospital.
Recruitment status was: Recruiting
First Posted : September 15, 2005
Last Update Posted : November 24, 2005
Polycystic ovary syndrome (PCOS) phenotype can be structured into three components: anovulation, hyperandrogenism and the metabolic syndrome (of which hyperinsulinemia, secondary to insulin resistance, is the central abnormality)(1). It is the most common endocrinologic disease seen in Gynecologic clinic. The follicular excess in polycystic ovaries and the failure of selection of one dominant follicle contribute to the anovulation of PCOS. The infertile PCOS female usually suffered from difficult ovulation induction and high risk of ovarian hyperstimulation syndrome because of extensive stimulation.
PCOS is the main androgen disorder in women and has been suggested to be associated with a high risk of developing cardiovascular disease and type-2 diabetes. In many PCOS patients, overweight or central obesity is generally associated with increases in fasting insulin levels, insulin resistance, and glucose intolerance, and has been identified as a target for new therapeutic strategy, including early change in lifestyle.
Insulin resistance, defined as decreased insulin-mediated glucose utilization, is commonly (10-25%) found in the normal population. In women with PCOS, insulin resistance appears even more common (up to 50%), in both obese and non-obese women.Hyperinsulinemia appears to play a key pathogenic role in the ovarian androgen overproduction, because of the stimulatory effect of insulin on ovarian steroid production.
|Condition or disease|
|Polycystic Ovary Syndrome Insulin Resistance Obesity|
|Study Type :||Observational|
|Enrollment :||500 participants|
|Official Title:||The Role of Insulin Resistance and Adiponectin in the Pathogenesis of Polycystic Ovary Syndrome|
|Study Start Date :||October 2004|
|Study Completion Date :||August 2005|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00173043
|Contact: Chen Mei-Jou, MD||886-2-23123456 ext firstname.lastname@example.org|
|National Taiwan University Hospital||Recruiting|
|Taipei, Taiwan, 100|
|Contact: Chen Mei-Jou, MD 886-2-23123456 ext 3950 email@example.com|
|Principal Investigator:||Yang Yu-Shih, M.D., PhD||Department of Obstetrics and Gynecology, NTUH|