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The Role of SNP of ECM and MMP on the Development of Pathological High Myopia

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 12, 2005
Last updated: NA
Last verified: June 2005
History: No changes posted
To study the clinical characteristics and inheritance of pathological myopia in Taiwanese patients.


Study Type: Observational
Study Design: Observational Model: Case Control
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Retrospective/Prospective
Official Title: National Taiwan University Hospital

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 600
Study Start Date: June 2005
Estimated Study Completion Date: January 2006
Detailed Description:
High myopia (pathological myopia) is caused by excessive axial elongation that primarily involves the ora-equatorial area and the posterior pole. Pathological myopia often accompanied by glaucoma, cataracts, macular degeneration, and retinal detachment, leading to blindness when the damage to the retina is extremely severe. Population and family studies in Chinese have provided evidence for a geneticcomponent to pathologic myopia. Children of myopic parents are more likely to have myopia than are children of nonmyopic parents. Therefore, it is possible to search a potential candidate gene for myopia through the genomic study of pathological myopia. The retina receives the signal from the retina-RPE complexes and affects the growth of scleral coats. The changes of scleral components, collagen fibrils and proteoglycans, are noted in experimental and human myopia and induce the pathology of high myopia. It is interesting to know that individual difference of SNP in the components of scleral coat affects the response to the signal from retina-RPE complexes. The most important effectors in scleral coats are collagens, proteoglycans, MMPs and TIMPs. Therefore, the difference of SNPs in different genes might contribute the formation of scleral thinning during myopia development. In this project, we will focus on this subject by using GenomeLab SNPstream Genotyping System which is powerful and helpful for identify some specific SNPs in the regard.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • They are unrelated Chinese subjects with high myopia ≦-6.00D. The diagnosis of myopia is determined by the refractive error. Anisometropic individuals, with a refractive error of ≦-6.00 D for one eye and ≦-6.00 D for the other eye, with at least a 2-D difference between the two eyes, are considered unaffected

Exclusion Criteria:

  • Individuals are excluded if there is known ocular disease or insult that could predispose to myopia, such as retinopathy of prematurity or early-age media opacification, or if they had a known genetic disease associated with myopia, such as Stickler or Marfan syndrome.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00172952

Contact: Yung-Feng Shih, MD 886-2-23123456 ext 5184

National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Yung-Feng Shih, MD    886-2-23123456 ext 5184   
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Yung-Feng Shih, MD National Taiwan University Hospital
  More Information Identifier: NCT00172952     History of Changes
Other Study ID Numbers: 9461700339
Study First Received: September 12, 2005
Last Updated: September 12, 2005

Keywords provided by National Taiwan University Hospital:
high myopia, genomic

Additional relevant MeSH terms:
Refractive Errors
Eye Diseases processed this record on September 21, 2017