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Use of Procalcitonin in the Diagnosis of Pleural Effusion

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ClinicalTrials.gov Identifier: NCT00172835
Recruitment Status : Unknown
Verified March 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 15, 2005
Last Update Posted : September 15, 2005
Sponsor:
Information provided by:
National Taiwan University Hospital

Brief Summary:
Among several markers of inflammation and sepsis, procalcitonin (PCT) markers is being studied to investigate their accuracy for the diagnosis of bacterial infections. PCT is the prehormone of calcitonin, which is normally secreted by the C cells of the thyroid in response to hypercalcemia; under these normal conditions, negligible serumPCT concentrations are detected. The mechanism proposed for PCT production after inflammation and its role are still not completely known. It is believed that PCT is produced by the liver and peripheral blood mononuclear cells, modulated by lipopolysaccharides and sepsis-related cytokines. It binds to polysaccharides in pathogens, activating the classical complement pathway. The reported diagnostic accuracy of PCT for the diagnosis of bacterial infections has varied across studies.

Condition or disease
Pleural Effusion

Study Type : Observational
Enrollment : 100 participants
Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Evaluation of Procalcitonin as a Diagnostic Tool for Patients With Pleural Effusion
Study Start Date : March 2005




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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Clinical diagnosis of pleural effusion
  • Pleural effusion proved by chest sonography

Exclusion Criteria:

  • Conditions for which thoracentesis are contraindicated
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00172835


Contacts
Contact: Po-Ren Hsueh, MD 886-2-2356-5363 prhsueh@ntumc.org

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Po-Ren Hsueh, MD    776-2-23565363    prhsueh@ntumc.org   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Po-Ren Hsueh, MD Department of Laboratory Medicine, National Taiwan University Hospital

ClinicalTrials.gov Identifier: NCT00172835     History of Changes
Other Study ID Numbers: 9461700208
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: September 15, 2005
Last Verified: March 2005

Keywords provided by National Taiwan University Hospital:
pleural effusion
procalcitonin

Additional relevant MeSH terms:
Pleural Effusion
Pleural Diseases
Respiratory Tract Diseases
Calcitonin
Bone Density Conservation Agents
Physiological Effects of Drugs