The Roles of Cytokines in the Mechanism of Insulin Resistance and Energy Balance

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00172614
Recruitment Status : Unknown
Verified December 2004 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 15, 2005
Last Update Posted : March 29, 2006
Information provided by:
National Taiwan University Hospital

Brief Summary:
Insulin resistance and disturbances in energy homeostasis are associated with body weight changes, such as diabetes, hypertension, hyperlipidemia, obesity, cancer cachexia, aging, and acute or chronic infectious diseases. Cytokines secreted by adipose tissue and inflammatory cells play important roles in the pathological conditions. Several novel cytokines were disclosed recently, but their functions have not been well known. Further investigation of these cytokines, resulting in insulin resistance and energy homeostasis, is very important to elucidate the mechanisms and develop new therapeutic strategies.

Condition or disease
Metabolic Syndrome X Cachexia Insulin Resistance

Detailed Description:
We are studying patients with body weight change, increased or decreased. Healthy people are the control group. We are recording body weight, body height, and physical exam results. In addition, we are drawing peripheral blood for further biochemical and cytokine assays.

Study Type : Observational
Enrollment : 300 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Study Start Date : December 2004

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Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Insulin resistance condition

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00172614

Contact: Jaw-Shiun Tsai, MD 886-2-23123456 ext 5349

National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Jaw-Shiun Tsai, MD         
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Jaw-Shiun Tsai, MD National Taiwan University Hospital Identifier: NCT00172614     History of Changes
Other Study ID Numbers: 9361701201
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: March 29, 2006
Last Verified: December 2004

Keywords provided by National Taiwan University Hospital:
metabolic syndrome

Additional relevant MeSH terms:
Metabolic Syndrome X
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Weight Loss
Body Weight Changes
Body Weight
Signs and Symptoms