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Metabolic Disorders in Polycystic Ovarian Syndrome

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ClinicalTrials.gov Identifier: NCT00172523
Recruitment Status : Unknown
Verified October 2004 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 15, 2005
Last Update Posted : September 15, 2005
Information provided by:

Study Description
Brief Summary:
The purpose of this study is to elucidate the significance of adipocytokine in women with PCOS among adiposity, hyperandrogenism and insulin resistance.

Condition or disease
Polycystic Ovary Syndrome

Detailed Description:
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age with a probable prevalence of 5% to 10%. PCOS is characterized by chronic anovulation, menstrual irregularities, evidence of hyperandrogenism (either clinical, manifested as hirsutism, acne, male pattern balding, or biochemical, manifested by elevated serum adrenal and/or ovarian androgen concentration). Fifty percent of all patients with PCOS are obese, and the presence of obesity affects the clinical manifestations of PCOS. The underlying pathogenic mechanisms appear to involve insulin resistance and hyperinsulinemia, the magnitude of which is greater in obese than in non-obese women with PCOS.

Study Design

Study Type : Observational
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Study Start Date : October 2004
Estimated Study Completion Date : August 2005

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   17 Years to 40 Years   (Child, Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 1. Oligomenorrhea ( less than 6 times spontaneous MC per year) or Amenorrhea. 2. Hyperandrogenism (either clinical or biochemistry. 3. PCO by ultrasound. 4.After menarche, before menopause.

Exclusion Criteria:

  • 1. hormone therapy in the past 6 months. 2. Pregnancy in the past 6 months 3.Acute illness found in the past 3 months. 4.Systemic disease including autoimmune disease, malignancy, hepatic, renal or CVS disease, and ever received chemotherapy or immunosuppressive agents.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00172523

Contact: Mei-Jou Chen, M.D. 886-2-23123456 ext 3950 metro@ha.mc.ntu.edu.tw

Department of Obstetrics and Gynecology, National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Mei-Jou Chen, M.D.    886-2-23123456 ext 3950    metro@ha.mc.tnu.edu.tw   
Sponsors and Collaborators
National Taiwan University Hospital
Study Director: Horng-Nerng Ho, M.D. NTUH
More Information

ClinicalTrials.gov Identifier: NCT00172523     History of Changes
Other Study ID Numbers: 9361701094
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: September 15, 2005
Last Verified: October 2004

Additional relevant MeSH terms:
Polycystic Ovary Syndrome
Pathologic Processes
Ovarian Cysts
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Gonadal Disorders
Endocrine System Diseases