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The Relationship Between Sleep Disorders and Cytokine Levels Among Hemodialysis and Peritoneal Dialysis Patients

This study has been completed.
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 12, 2005
Last updated: December 20, 2005
Last verified: December 2004

Sleep disorders are common in patients with end-stage renal disease on both hemodialysis and peritoneal dialysis and are associated with significant medical, psychological and social disturbances. Numerous factors have been suggested as contributing to or associated with the high prevalence of sleep disturbance in this population.

Increasing evidence suggests that cytokines are involved in the regulation of sleep and wakefulness and that the communication between the sleep and the immune system is bi-directional. Blood-dialyzer or peritoneum-dialysate interaction during dialysis therapy has the potential to activate mononuclear cells leading to production of inflammatory cytokines. These cytokines are believed to play a significant role in dialysis-associated morbidity and mortality. Nevertheless, a cytokine overproduction may alter sleep pattern in chronic dialyzed patients, thus explaining the presence of sleep disorders in these patients. In the other way, sleep loss may have effects on immune process and secretion of cytokines in chronic dialyzed patients. The purpose of this study was to examine the relationship between quality of sleep and serum cytokine levels in hemodialysis and peritoneal dialysis patients.

Renal Failure Sleep Disorder Hemodialysis Peritoneal Dialysis

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Retrospective/Prospective

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • ESRD Patients with hemodialysis or peritoneal dialysis

Exclusion Criteria:

  • Malignancy, hospitalization, infection, inflammation
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Please refer to this study by its identifier: NCT00172471

Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Jenq-Wen Huang, MD Department of Internal Medicine, National Taiwan University Hospital
  More Information Identifier: NCT00172471     History of Changes
Other Study ID Numbers: 9361700775
Study First Received: September 12, 2005
Last Updated: December 20, 2005

Additional relevant MeSH terms:
Renal Insufficiency
Sleep Wake Disorders
Kidney Diseases
Urologic Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders processed this record on September 21, 2017