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Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2005 by National Taiwan University Hospital.
Recruitment status was:  Not yet recruiting
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 12, 2005
Last updated: NA
Last verified: May 2005
History: No changes posted
Intravenous vitamin C may improve skin hyperpigmentation in chronic hemodialysis patients

Condition Intervention
Kidney Failure, Chronic
Drug: vitamin C, intravenous injection

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • Skin pigmentation extent

Secondary Outcome Measures:
  • blood anti-oxidant level

Estimated Enrollment: 40
Study Start Date: November 2005
Detailed Description:
Melanogenesis is caused by enzymatic conversion of tyrosine to melanin pigments.Ascorbic acid has the ability to inhibit peroxidase and may thus inhibit melanin synthesis.

Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • chronic hemodialysis patients

Exclusion Criteria:

  • allergic to vitamin C, using steroid, etc
  Contacts and Locations
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Please refer to this study by its identifier: NCT00172302

National Taiwan University Hospital Not yet recruiting
Taipei, Taiwan, 100
Contact: Tze-Wah Kao, MD    886-2-2356-2000   
Principal Investigator: Tze-Wah Kao, MD         
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Kao Tze-Wah, MD National Taiwan University Hospital
  More Information Identifier: NCT00172302     History of Changes
Other Study ID Numbers: 930105
Study First Received: September 12, 2005
Last Updated: September 12, 2005

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Failure, Chronic
Kidney Diseases
Urologic Diseases
Renal Insufficiency, Chronic
Pigmentation Disorders
Skin Diseases
Ascorbic Acid
Growth Substances
Physiological Effects of Drugs
Molecular Mechanisms of Pharmacological Action
Protective Agents processed this record on May 25, 2017