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Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?

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ClinicalTrials.gov Identifier: NCT00172302
Recruitment Status : Unknown
Verified May 2005 by National Taiwan University Hospital.
Recruitment status was:  Not yet recruiting
First Posted : September 15, 2005
Last Update Posted : September 15, 2005
Sponsor:
Information provided by:
National Taiwan University Hospital

Brief Summary:
Intravenous vitamin C may improve skin hyperpigmentation in chronic hemodialysis patients

Condition or disease Intervention/treatment Phase
Kidney Failure, Chronic Drug: vitamin C, intravenous injection Not Applicable

Detailed Description:
Melanogenesis is caused by enzymatic conversion of tyrosine to melanin pigments.Ascorbic acid has the ability to inhibit peroxidase and may thus inhibit melanin synthesis.

Study Type : Interventional  (Clinical Trial)
Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?
Study Start Date : November 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Dialysis Vitamin C




Primary Outcome Measures :
  1. Skin pigmentation extent

Secondary Outcome Measures :
  1. blood anti-oxidant level


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • chronic hemodialysis patients

Exclusion Criteria:

  • allergic to vitamin C, using steroid, etc

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00172302


Locations
Taiwan
National Taiwan University Hospital Not yet recruiting
Taipei, Taiwan, 100
Contact: Tze-Wah Kao, MD    886-2-2356-2000    twkao@ha.mc.ntu.edu.tw   
Principal Investigator: Tze-Wah Kao, MD         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Kao Tze-Wah, MD National Taiwan University Hospital

ClinicalTrials.gov Identifier: NCT00172302     History of Changes
Other Study ID Numbers: 930105
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: September 15, 2005
Last Verified: May 2005

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Failure, Chronic
Hyperpigmentation
Kidney Diseases
Urologic Diseases
Renal Insufficiency, Chronic
Pigmentation Disorders
Skin Diseases
Vitamins
Ascorbic Acid
Micronutrients
Growth Substances
Physiological Effects of Drugs
Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents