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Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2005 by National Taiwan University Hospital.
Recruitment status was:  Not yet recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00172302
First Posted: September 15, 2005
Last Update Posted: September 15, 2005
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Taiwan University Hospital
  Purpose
Intravenous vitamin C may improve skin hyperpigmentation in chronic hemodialysis patients

Condition Intervention
Kidney Failure, Chronic Drug: vitamin C, intravenous injection

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • Skin pigmentation extent

Secondary Outcome Measures:
  • blood anti-oxidant level

Estimated Enrollment: 40
Study Start Date: November 2005
Detailed Description:
Melanogenesis is caused by enzymatic conversion of tyrosine to melanin pigments.Ascorbic acid has the ability to inhibit peroxidase and may thus inhibit melanin synthesis.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • chronic hemodialysis patients

Exclusion Criteria:

  • allergic to vitamin C, using steroid, etc
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00172302


Locations
Taiwan
National Taiwan University Hospital Not yet recruiting
Taipei, Taiwan, 100
Contact: Tze-Wah Kao, MD    886-2-2356-2000    twkao@ha.mc.ntu.edu.tw   
Principal Investigator: Tze-Wah Kao, MD         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Kao Tze-Wah, MD National Taiwan University Hospital
  More Information

ClinicalTrials.gov Identifier: NCT00172302     History of Changes
Other Study ID Numbers: 930105
First Submitted: September 12, 2005
First Posted: September 15, 2005
Last Update Posted: September 15, 2005
Last Verified: May 2005

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Failure, Chronic
Hyperpigmentation
Kidney Diseases
Urologic Diseases
Renal Insufficiency, Chronic
Pigmentation Disorders
Skin Diseases
Vitamins
Ascorbic Acid
Micronutrients
Growth Substances
Physiological Effects of Drugs
Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents