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Measurement of Pulse Wave Velocity in Spinal Cord Injury and Stroke Patients

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2004 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00172289
First Posted: September 15, 2005
Last Update Posted: January 9, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Taiwan University Hospital
  Purpose

According to the theory of wave transmission, the speed of wave transmission is dependent on the nature of the transmission medium, which is the vessel wall for pulse wave transmission. Then, the pulse wave velocity is related to the mechanical property of the vessel wall. The mechanical property of the vessel wall is determined by the texture of the vessel wall and the contraction status of the smooth muscle within the vessel wall. Because the texture of the vessel wall could not be changed in a short duration, the sympathetic nerve activity, which controls the contractibility of the smooth muscle, becomes the only determinant factor of pulse wave velocity. So, pulse wave velocity may reflect the status of sympathetic nerve activity. The purpose of this project is to use the pulse wave velocity to measure the sympathetic activity of stroke and spinal cord patients. The present project plans to measure the pulse wave simultaneously at four limbs by pressure receptors, and use the electrocardiogram as the reference to synchronize the recorded pulse wave at different vessels, using the corrected data to calculate the pulse wave velocity. With the pulse wave velocity of different vessels, we, the investigators at National Taiwan University Hospital, can understand the local sympathetic nerve activity in different diseases and different sites.

The first year, we will set up the equipment for measuring the pulse wave velocity, and then apply it to 20 healthy subjects to adjust the measurement error and ascertain the reproducibility of the machine. The second year, we will apply the measurement to 15 complete cervical cord injury individuals and 15 healthy subjects in different erected angles by a tilting table. This procedure will make us understand the response of sympathetic nerve activity to different postures in normal subjects and cervical cord injury patients. The third year, we will apply the measurement to 30 cerebrovascular accident patients to understand the change of sympathetic nerve activity after having a stroke. By comparing the clinical information, we hope to clear up the relationship between sympathetic nerve activity and pulse wave velocity.


Condition
Cerebrovascular Accident Spinal Cord Injury

Study Type: Observational
Study Design: Observational Model: Case Control
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Measurement of Pulse Wave Velocity in Spinal Cord Injury and Stroke Patients

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 80
Study Start Date: August 2004
Estimated Study Completion Date: December 2006
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Stroke patients with shoulder pain
  • Spinal cord injury patients with complete cervical lesion

Exclusion Criteria:

  • Peripheral vascular disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00172289


Contacts
Contact: Wang Tyng-Guey, MD 886-2-23123456 ext 7588 tgw@ha.mc.ntu.edu.tw

Locations
Taiwan
Wang Tyng-Guey Recruiting
Taipei, Taiwan
Contact: Wang Tyng-Guey, MD    886-2-23123456 ext 7588    tgw@ha.mc.ntu.edu.tw   
Principal Investigator: Wang Chung-Li         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Study Director: Wang Tyng-Guey, MD National Taiwan University, School of Medicine, National Taiwan University
  More Information

ClinicalTrials.gov Identifier: NCT00172289     History of Changes
Other Study ID Numbers: 9261701395
First Submitted: September 12, 2005
First Posted: September 15, 2005
Last Update Posted: January 9, 2006
Last Verified: December 2004

Keywords provided by National Taiwan University Hospital:
pulse wave velocity
sympathetic nerve activity
spinal cord injury
cerebrovascular accident

Additional relevant MeSH terms:
Wounds and Injuries
Spinal Cord Injuries
Stroke
Spinal Cord Diseases
Central Nervous System Diseases
Nervous System Diseases
Trauma, Nervous System
Cerebrovascular Disorders
Brain Diseases
Vascular Diseases
Cardiovascular Diseases