Measurement of Pulse Wave Velocity in Spinal Cord Injury and Stroke Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00172289
Recruitment Status : Unknown
Verified December 2004 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 15, 2005
Last Update Posted : January 9, 2006
Information provided by:
National Taiwan University Hospital

Brief Summary:

According to the theory of wave transmission, the speed of wave transmission is dependent on the nature of the transmission medium, which is the vessel wall for pulse wave transmission. Then, the pulse wave velocity is related to the mechanical property of the vessel wall. The mechanical property of the vessel wall is determined by the texture of the vessel wall and the contraction status of the smooth muscle within the vessel wall. Because the texture of the vessel wall could not be changed in a short duration, the sympathetic nerve activity, which controls the contractibility of the smooth muscle, becomes the only determinant factor of pulse wave velocity. So, pulse wave velocity may reflect the status of sympathetic nerve activity. The purpose of this project is to use the pulse wave velocity to measure the sympathetic activity of stroke and spinal cord patients. The present project plans to measure the pulse wave simultaneously at four limbs by pressure receptors, and use the electrocardiogram as the reference to synchronize the recorded pulse wave at different vessels, using the corrected data to calculate the pulse wave velocity. With the pulse wave velocity of different vessels, we, the investigators at National Taiwan University Hospital, can understand the local sympathetic nerve activity in different diseases and different sites.

The first year, we will set up the equipment for measuring the pulse wave velocity, and then apply it to 20 healthy subjects to adjust the measurement error and ascertain the reproducibility of the machine. The second year, we will apply the measurement to 15 complete cervical cord injury individuals and 15 healthy subjects in different erected angles by a tilting table. This procedure will make us understand the response of sympathetic nerve activity to different postures in normal subjects and cervical cord injury patients. The third year, we will apply the measurement to 30 cerebrovascular accident patients to understand the change of sympathetic nerve activity after having a stroke. By comparing the clinical information, we hope to clear up the relationship between sympathetic nerve activity and pulse wave velocity.

Condition or disease
Cerebrovascular Accident Spinal Cord Injury

  Show Detailed Description

Study Type : Observational
Enrollment : 80 participants
Observational Model: Case Control
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Measurement of Pulse Wave Velocity in Spinal Cord Injury and Stroke Patients
Study Start Date : August 2004
Study Completion Date : December 2006

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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Stroke patients with shoulder pain
  • Spinal cord injury patients with complete cervical lesion

Exclusion Criteria:

  • Peripheral vascular disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00172289

Contact: Wang Tyng-Guey, MD 886-2-23123456 ext 7588

Wang Tyng-Guey Recruiting
Taipei, Taiwan
Contact: Wang Tyng-Guey, MD    886-2-23123456 ext 7588   
Principal Investigator: Wang Chung-Li         
Sponsors and Collaborators
National Taiwan University Hospital
Study Director: Wang Tyng-Guey, MD National Taiwan University, School of Medicine, National Taiwan University Identifier: NCT00172289     History of Changes
Other Study ID Numbers: 9261701395
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: January 9, 2006
Last Verified: December 2004

Keywords provided by National Taiwan University Hospital:
pulse wave velocity
sympathetic nerve activity
spinal cord injury
cerebrovascular accident

Additional relevant MeSH terms:
Wounds and Injuries
Spinal Cord Injuries
Spinal Cord Diseases
Central Nervous System Diseases
Nervous System Diseases
Trauma, Nervous System
Cerebrovascular Disorders
Brain Diseases
Vascular Diseases
Cardiovascular Diseases