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The Interaction Between Severe Acute Respiratory Distress Syndrome Viral Proteins and Monocytes

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00172263
Recruitment Status : Withdrawn
First Posted : September 15, 2005
Last Update Posted : December 10, 2012
Information provided by:
National Taiwan University Hospital

Brief Summary:

Severe acute respiratory syndrome (SARS) is a new threat to public health since November, 2002. The SARS is highly contagious and is believed to be transmitted by person-to-person through droplet and direct contact. The patients present with fever, chills, cough, myalgia, dyspnea, and diarrhea. The symptoms aggravate in the second week and nearly 40% of the patients develop respiratory failure that requires assisted ventilation. The mortality rate is reported as 6.5%-7%.

After several months, the world scientists found the etiology to be a new coronavirus not belonging to the previous coronavirus group I, II and III. The new virus is called SARS associated coronavirus (SARS-CoV).

Although the high morbidity and mortality of SARS occurred in adults, there was rare mortality reported in the children. The report from Hong Kong pointed out that the symptoms of SARS in younger children were milder and the clinical course was not as aggressive as in adults. Therefore, the aim of the project is to design the experiment to see the differences of immunological responses to SARS-CoV protein in healthy younger children, teenagers, and adults. The investigators hope that the result could explain the reason for milder disease in younger children and the immunological pathogenesis of SARS.

Condition or disease Intervention/treatment Phase
Severe Acute Respiratory Syndrome Procedure: blood sampling Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 0 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy adults, children and cord blood

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00172263

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China, Taiwan
Li-Chieh Wang, MD
Taipei, Taiwan, China, 100
Sponsors and Collaborators
National Taiwan University Hospital
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Principal Investigator: Li-Chieh Wang, MD National Taiwan University Hospital
Layout table for additonal information Identifier: NCT00172263    
Other Study ID Numbers: 9261701054
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: December 10, 2012
Last Verified: December 2012
Keywords provided by National Taiwan University Hospital:
Additional relevant MeSH terms:
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Severe Acute Respiratory Syndrome
Pathologic Processes
Respiratory Tract Infections
Coronavirus Infections
Coronaviridae Infections
Nidovirales Infections
RNA Virus Infections
Virus Diseases
Respiratory Tract Diseases