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The Interaction Between Severe Acute Respiratory Distress Syndrome Viral Proteins and Monocytes

This study has been withdrawn prior to enrollment.
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 12, 2005
Last updated: December 6, 2012
Last verified: December 2012

Severe acute respiratory syndrome (SARS) is a new threat to public health since November, 2002. The SARS is highly contagious and is believed to be transmitted by person-to-person through droplet and direct contact. The patients present with fever, chills, cough, myalgia, dyspnea, and diarrhea. The symptoms aggravate in the second week and nearly 40% of the patients develop respiratory failure that requires assisted ventilation. The mortality rate is reported as 6.5%-7%.

After several months, the world scientists found the etiology to be a new coronavirus not belonging to the previous coronavirus group I, II and III. The new virus is called SARS associated coronavirus (SARS-CoV).

Although the high morbidity and mortality of SARS occurred in adults, there was rare mortality reported in the children. The report from Hong Kong pointed out that the symptoms of SARS in younger children were milder and the clinical course was not as aggressive as in adults. Therefore, the aim of the project is to design the experiment to see the differences of immunological responses to SARS-CoV protein in healthy younger children, teenagers, and adults. The investigators hope that the result could explain the reason for milder disease in younger children and the immunological pathogenesis of SARS.

Condition Intervention
Severe Acute Respiratory Syndrome
Procedure: blood sampling

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Enrollment: 0

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy adults, children and cord blood
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Please refer to this study by its identifier: NCT00172263

China, Taiwan
Li-Chieh Wang, MD
Taipei, Taiwan, China, 100
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Li-Chieh Wang, MD National Taiwan University Hospital
  More Information Identifier: NCT00172263     History of Changes
Other Study ID Numbers: 9261701054
Study First Received: September 12, 2005
Last Updated: December 6, 2012

Keywords provided by National Taiwan University Hospital:

Additional relevant MeSH terms:
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Severe Acute Respiratory Syndrome
Coronavirus Infections
Pathologic Processes
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Lung Injury
Coronaviridae Infections
Nidovirales Infections
RNA Virus Infections
Virus Diseases
Respiratory Tract Infections processed this record on April 28, 2017