A Study to Evaluate the Efficacy and Tolerability of Zoledronic Acid in Patients With Metastatic Prostate Cancer Who Can be Treated With a Group of Medications Known as Bisphosphonates
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Written informed consent must be obtained
Age > 18 years
Histologically confirmed diagnosis of carcinoma of the prostate
Current (or previous) objective evidence of metastatic disease to the bone
Currently receiving 1st line hormonal therapy with LHRH agonists or other hormonal treatments
ECOG performance status of 0, 1, or 2
Patients with abnormal renal function as evidenced by either a serum creatinine determination 1.5 x or greater above the upper limit of normal or by a calculated creatinine clearance of 60 ml/minute or less