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Acute Viral Respiratory Infections in Elderly

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ClinicalTrials.gov Identifier: NCT00170495
Recruitment Status : Terminated
First Posted : September 15, 2005
Last Update Posted : August 27, 2010
Sponsor:
Information provided by:

Study Description
Brief Summary:
This study is designed to assess the causes and impact of acute respiratory illness (common colds, flu, bronchitis, pneumonia) in adults age 65 and older. One of the ways to determine the virus causing a particular illness is to get a blood specimen when a person is sick and again later and look for the body's specific responses that identify the virus. Approximately 3000 subjects will be evaluated and their medical records assessed for details of recent illness and general health to help in understanding the subjects' current illness.

Condition or disease
Respiratory Infections, Acute

Detailed Description:
The purpose of this study is to determine the role of respiratory viruses in the etiology of medically attended acute respiratory illness in elderly populations and to assess the impact of these illnesses. Ambulatory elders presenting for health care with an acute respiratory illness will be recruited. Nose and throat swab specimens will be collected to test for one of the respiratory viruses, and acute and convalescent blood specimens will be collected to test for increases in specific antibody. Specimens will be collected within seven days of the onset of illness and then 1 month later for comparison specimens. A brief questionnaire will accompany the specimens, and more complete data on the illness and consequences will be obtained from the medical record. The pattern of illnesses by virus and their severity and duration will be determined.

Study Design

Study Type : Observational
Actual Enrollment : 3000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Etiology and Impact of Acute Viral Respiratory Infections in Ambulatory Elderly Populations
Study Start Date : September 2004
Primary Completion Date : July 2006
Study Completion Date : July 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Acute Bronchitis
U.S. FDA Resources

Groups and Cohorts

Group/Cohort
observation
male and female adults age 65 and older with acute respiratory illness (common colds, flu, bronchitis, pneumonia)


Outcome Measures

Biospecimen Retention:   Samples Without DNA
blood, sputum, nasal and throat swabs

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
male and female adults age 65 and older with acute respiratory illness (common colds, flu, bronchitis, pneumonia)
Criteria

Inclusion Criteria:

  1. 65 years of age or older
  2. Presentation to the geriatric clinic with an acute respiratory illness of less than 7 days' duration.

Exclusion Criteria:

  1. Presentation to the geriatric clinic with a history of a respiratory illness of greater than 7 days' duration.
  2. Physician/physician assistant judgment that the respiratory complaints do not represent an acute infection.
  3. Patient declines to permit specimen collection.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00170495


Locations
United States, Texas
Baylor College of Medicine
Houston, Texas, United States, 77030
Sponsors and Collaborators
National Institute of Allergy and Infectious Diseases (NIAID)
More Information

Responsible Party: Robert Johnson, HHS/NIAID/DMID
ClinicalTrials.gov Identifier: NCT00170495     History of Changes
Other Study ID Numbers: 04-049
H-14802
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: August 27, 2010
Last Verified: September 2008

Keywords provided by National Institute of Allergy and Infectious Diseases (NIAID):
respiratory illness, influenza, bronchitis, pneumonia, cold

Additional relevant MeSH terms:
Infection
Communicable Diseases
Respiratory Tract Infections
Respiratory Tract Diseases