Clinical, Molecular and Metabolic Characteristics of Parkinson's Disease (PD) Patients With Parkin Mutation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00169364
Recruitment Status : Unknown
Verified September 2005 by Groupe Hospitalier Pitie-Salpetriere.
Recruitment status was:  Recruiting
First Posted : September 15, 2005
Last Update Posted : August 29, 2007
Délégation Régionale à la Recherche Clinique
Information provided by:
Groupe Hospitalier Pitie-Salpetriere

Brief Summary:
Parkinson's disease is a frequent neurodegenerative disorder. Genetic forms of the disease have been recently identified. The monogenic form due to parkin mutation is responsible for many familial cases and sporadic forms. However, the relationship between the mutation and the genotype of patients is not fully established. The aim of this study is to compare clinical, metabolic and neuropsychological characteristics obtained in patients with parkin mutation with those of patients without parkin mutation.

Condition or disease Intervention/treatment Phase
Parkinson's Disease Device: positron emission tomography Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 50 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Comparison of Clinical, Molecular and Metabolic Characteristics of PD Patients With and Without Parkin Mutation
Study Start Date : May 2002

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Parkin mutation
  2. Motor disability
  3. Neuropsychological evaluation
  4. Psychiatric evaluation

Secondary Outcome Measures :
  1. Positron emission tomography

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Juvenile Parkinson's disease (< 45 years)
  • Parkin mutation
  • Normal brain magnetic resonance imaging (MRI)

Exclusion Criteria:

  • Contraindication to brain MRI
  • Women without effective contraception

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00169364

Contact: Alexis Brice, MD, PhD 33-142162183

Centre d'Investigation Clinique-Hôpital Pitié-Salpetriere Recruiting
Paris, France
Contact: Marie-Laure Welter, MD    33-142161950   
Principal Investigator: Alexis Brice, MD, PhD         
Sponsors and Collaborators
Groupe Hospitalier Pitie-Salpetriere
Délégation Régionale à la Recherche Clinique
Study Director: Alexis Brice, MD, PhD Groupe Hospitalier Pitié-Salpêtrière Identifier: NCT00169364     History of Changes
Other Study ID Numbers: P011104
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: August 29, 2007
Last Verified: September 2005

Keywords provided by Groupe Hospitalier Pitie-Salpetriere:
Parkinson's disease
parkin mutation
Juvenile parkinson's disease
positron emission tomography

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases