This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Enteral Nutrition in Liver Cirrhosis

This study has been completed.
Information provided by:
Charite University, Berlin, Germany Identifier:
First received: September 13, 2005
Last updated: May 6, 2010
Last verified: September 2005

Malnutrition is frequently occurring in patients with liver cirrhosis and is associated with a poorer outcome, as it determines life quality and affects both morbidity and mortality.

Long term prognosis after liver transplantation also depends on the nutritional status.

Therefore, the early diagnosis and intervention for malnutrition is an important issue in the clinical management of liver cirrhosis. However, oral intake has been shown to be insufficient due to disease related anorexia or concomitant drowsiness and confusion.

Specific aims: To investigate the effect of early nutritional intervention via tube feeding on nutritional status, functional status (hand grip strength and peak flow), life quality and disease related complications such as intestinal permeability, and oxidative stress, as well as liver function.

Condition Intervention Phase
Liver Cirrhosis Dietary Supplement: High Protein Energy, Fresenius-Kabi (nutritional intervention) Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)

Resource links provided by NLM:

Further study details as provided by Charite University, Berlin, Germany:

Study Start Date: December 2003
Study Completion Date: June 2007
Primary Completion Date: December 2006 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Liver cirrhosis (Child B or Child C)

Exclusion Criteria:

  • Malignant comorbidity
  • Encephalopathy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00168961

Charite Universitätsmedizin Klinik für Gastroenterologie
Berlin, Germany, 10117
Sponsors and Collaborators
Charite University, Berlin, Germany
Principal Investigator: Matthias Pirlich, MD Charite Universitätsmedizin CCM Klinik für Gastroenterologie
  More Information Identifier: NCT00168961     History of Changes
Other Study ID Numbers: EE1
Study First Received: September 13, 2005
Last Updated: May 6, 2010

Keywords provided by Charite University, Berlin, Germany:
liver cirrhosis Child B or C

Additional relevant MeSH terms:
Liver Cirrhosis
Pathologic Processes
Liver Diseases
Digestive System Diseases processed this record on August 18, 2017