Different Doses of Vitamin A Supplementation and Male and Female Morbidity and Mortality
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
|Official Title:||The Impact of Different Doses of Vitamin A Supplementation on Male and Female Childhood Morbidity and Mortality|
- All outcomes are investigated for interactions between vitamin A, sex, and last vaccine received
- Rota infection
- Measles infection
|Study Start Date:||November 2004|
|Primary Completion Date:||November 2013 (Final data collection date for primary outcome measure)|
In Guinea-Bissau, a combined OPV and VAS campaign took place in November 2002. Given the uncertainty about the best dose of VAS, we examined whether the half dose compared with the full dose currently recommended by WHO gave an equally good protection against childhood morbidity and mortality. Mortality after supplementation was lower, though not significantly so, for children who had received the half dose. However, there was a highly significant inversion of the effect for boys and girls; while the low dose was clearly better for girls, the full dose might have been slightly better for boys. The girls' responses to the high versus the low dose of vitamin A might have depended on the last vaccine received before the OPV and VAS campaign.
We believe that these findings call for confirmation. In connection with the OPV and VAS campaign in November 2004 in Guinea-Bissau, we intend to examined whether half the dose of the dose currently recommended by WHO as compared to the full dose has a more beneficial effect on mortality and morbidity in girls, and furthermore address the potential effect modification by the last vaccine received before the supplementation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00168636
|Bandim Health Project, Apartado 861|
|Principal Investigator:||Peter Aaby, DMSc||Bandim Health Project|