Genotoxicity Assessment for Patients Undergoing Radiation Treatment
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|ClinicalTrials.gov Identifier: NCT00167427|
Recruitment Status : Recruiting
First Posted : September 14, 2005
Last Update Posted : January 12, 2018
|Condition or disease|
Correlative studies: analysis of RT effect on genotoxicity by assessing cytogenetic changes (dicentrics), micronucleated lymphocytes (MN-lymph), and micronucleated reticulocytes (MN-RET) using peripheral blood of patients receiving radiation.
i) document the kinetics by which radiation-induced MN-RET enter the peripheral blood stream.
ii) benchmark the MN-RET endpoint against current gold-standard biodosimetry endpoints—dicentrics and MN-lymphocytes.
iii) measure inter-individual variation in baseline and radiation-induced MN-RET frequencies.
iv) in collaboration with several FCM-equipped laboratories, evaluate the transferability of the human MN-RET scoring assay.
|Study Type :||Observational|
|Estimated Enrollment :||120 participants|
|Official Title:||Genotoxicity Assessment for Patients Receiving Large Field Irradiation|
|Study Start Date :||April 2006|
|Estimated Primary Completion Date :||October 2018|
|Estimated Study Completion Date :||October 2018|
- Measure the Change in MN-RET in the blood [ Time Frame: Baseline and 1 day ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00167427
|Contact: Therese Smudzin, BSfirstname.lastname@example.org|
|Contact: Yuhchyau Chen, MD, Ph.Demail@example.com|
|United States, New York|
|University of Rochester, Dept. Radiation Oncology||Recruiting|
|Rochester, New York, United States, 14642|
|Contact: Yuhchayau Chen, MD, Ph.D.|
|Principal Investigator: Yuhchyau Chen, MD, Ph.D|
|Principal Investigator:||Yuhchyau Chen, MD, Ph.D||Universtiy of Rochester, Dept of Radiation Oncology|