Molecular Mechanism of Trophinin in Cancer Invasion and Metastasis
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|ClinicalTrials.gov Identifier: NCT00166972|
Recruitment Status : Completed
First Posted : September 14, 2005
Last Update Posted : September 14, 2005
|Condition or disease|
This study was to combine the in silico biology and empirical methods to identify clinically useful biomarker of lung cancer from microarray gene expression profiles in public database.
Using the expression profile of a known metastasis suppressor, CRMP-1, as a template to search for and compare transcriptome expressions in publicly accessible microarray datasets, trophinin (TRO) was identified as the best correlated gene. The expression pattern of trophinin in a lung cancer cell lines of invasion model was investigated using quantitative RT-PCR. The role of trophinin in cancer metastasis was investigated by measuring the change of invasion activity in trophinin gene-transfected cell lines. The relationship of trophinin and the clinicopathological characteristics of lung cancer were further examined by immunohistochemical staining.
|Study Type :||Observational|
|Enrollment :||150 participants|
|Observational Model:||Natural History|
|Official Title:||Molecular Mechanism of Trophinin in Cancer Invasion and Metastasis|
|Study Start Date :||January 2005|
|Study Completion Date :||April 2005|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00166972
|Principal Investigator:||Kuan-Yu Chen, M.D.||National Taiwan University Hospital|