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Use of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in the Diagnosis of Pleural Effusion

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 12, 2005
Last updated: November 23, 2005
Last verified: May 2005
The aim of this trial is to evaluate the level of TREM-1 in different kinds of pleural effusion.

Pleural Effusion

Study Type: Observational
Study Design: Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Evaluation of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) as a Diagnostic Tool for Patients With Pleural Effusion

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 100
Study Start Date: May 2005
Detailed Description:
The triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily, and its expression is upregulated on phagocytic cells in the presence of bacteria or fungi. Several experiments by Bouchon and colleagues showed that TREM-1 mediates the acute inflammatory response to microbial products. Human tissues infected with bacteria are infiltrated with neutrophils and macrophages that express high levels of TREM-1. Conversely, TREM-1 is only weakly expressed in samples from patients with noninfectious inflammatory disorders. In addition, TREM-1 is shed from the membrane of activated phagocytes and can be found in a soluble form in body fluids. The presence of a soluble form of TREM-1 in samples of bronchoalveolar lavage fluid from mechanically ventilated patients has been shown to be a good indicator of infectious pneumonia.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Clinical diagnosis of pleural effusion
  • Pleural effusion proved by chest sonography

Exclusion Criteria:

  • Conditions for which thoracentesis are contraindicated
  • Pregnancy
  Contacts and Locations
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Please refer to this study by its identifier: NCT00166894

Contact: Pan-Chyr Yang, MD, PhD 886-2-2356-2867

National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Pan-Chyr Yang, MD, PhD    886-2-2356-2867   
Principal Investigator: Pan-Chyr Yang, MD, PhD         
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Pan-Chyr Yang, MD, PhD Department of International Medicine, National Taiwan University Hospital
  More Information Identifier: NCT00166894     History of Changes
Other Study ID Numbers: 9461700516
Study First Received: September 12, 2005
Last Updated: November 23, 2005

Keywords provided by National Taiwan University Hospital:
pleural effusion

Additional relevant MeSH terms:
Pleural Effusion
Pleural Diseases
Respiratory Tract Diseases processed this record on May 25, 2017